NDLI: Origin of Two Modes of Non-isothermal Crystallization of Glasses Produced by Milling

Content Provider	Springer Nature Link
Author	Chattoraj, Sayantan Bhugra, Chandan Telang, Chitra Zhong, Li Wang, Zeren Sun, Changquan Calvin
Copyright Year	2011
Abstract	To mechanistically explain the origin of two distinct non-isothermal crystallization modes, single-peak (unimodal) and two-peak (bimodal), of organic glasses.Glasses of ten organic molecules were prepared by melt-quenching and cryogenic milling of crystals. Non-isothermal crystallization of glasses was monitored using differential scanning calorimetry and powder X-ray diffractometry.The non-isothermal crystallization of glass, generated by milling, is either unimodal or bimodal, while that of melt-quenched glass without being milled is always unimodal. The mode of crystallization of amorphous phase depends on the relative position of the crystallization onset (T $_{ c }$) with respect to glass transition temperature (T $_{ g }$), and can be explained by a surface crystallization model. Bimodal crystallization event is observed when T $_{ c }$ is below or near T $_{ g }$, due to the fast crystallization onset at milled glass surfaces. Unimodal crystallization is observed when T $_{ c }$ is well above T $_{ g }$. We have verified this model by intentionally inducing flip between the two crystallization modes for several compounds through manipulating glass surface area and T $_{ c }$.The two modes of crystallization of organic glasses is a result of the combined effects of faster surface crystallization and variation in specific surface area by milling.
Starting Page	1020
Ending Page	1032
Page Count	13
File Format	PDF
ISSN	07248741
Journal	Pharmaceutical Research
Volume Number	29
Issue Number	4
e-ISSN	1573904X
Language	English
Publisher	Springer US
Publisher Date	2011-12-16
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pharmacology/Toxicology Medical Law Biochemistry Biomedical Engineering Pharmacy
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science

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