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| Content Provider | Springer Nature Link |
|---|---|
| Author | Matsuo, Yumiko Ya, Ikuko Habu, Yasushi Katsura, Toshiya Hashimoto, Yukiya Inui, Ken ichi |
| Copyright Year | 2001 |
| Abstract | Purpose. To evaluate the mechanism of renal transport of quinolone antibacterial drugs, we examined the interaction of levofloxacin with p–aminohippurate (PAH) transport systems and the transport of levofloxacin in renal epithelial cells. Methods. Transport of [$^{14}$C]PAH or [$^{14}$C]levofloxacin was measured using OK cell monolayers grown on microporous membrane filters. Results. Transcellular transport from the basolateral to the apical side and cellular accumulation of [$^{14}$C]PAH were inhibited by levofloxacin. Both the initial uptake of [$^{14}$C]PAH from the basolateral side and the efflux to the apical side were inhibited by levofloxacin. The basolateral–to–apical transcellular transport of [$^{14}$C]levofloxacin was greater than that in the opposite direction. [$^{14}$C]Levofloxacin efflux to the apical side was greater than that to the basolateral side. Unlabeled levofloxacin and grepafloxacin inhibited the transcellular transport of [$^{14}$C]levofloxacin, accompanied by an increase of cellular accumulation. However, neither PAH nor an anion transport inhibitor 4–4′–diisothiocyanostilbene–2,2′–disulfonic acid (DIDS) affected the basolateral–to–apical transport of [$^{14}$C]levofloxacin nor its uptake from the basolateral side. Conclusions. These results indicated that levofloxacin inhibits PAH transport across both the basolateral and apical membranes of OK cells, but are not transported via the systems for PAH transport. The existence of a specific transport system for quinolones was indicated in OK cells. |
| Starting Page | 573 |
| Ending Page | 578 |
| Page Count | 6 |
| File Format | |
| ISSN | 07248741 |
| Journal | Pharmaceutical Research |
| Volume Number | 18 |
| Issue Number | 5 |
| e-ISSN | 1573904X |
| Language | English |
| Publisher | Kluwer Academic Publishers-Plenum Publishers |
| Publisher Date | 2001-01-01 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Pharmacology/Toxicology Pharmacy Biochemistry Medical Law Biomedical Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Pharmacology Molecular Medicine Pharmacology (medical) Biotechnology Pharmaceutical Science |
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