NDLI: Self-assembly and Self-replication of Short Amphiphilic β-sheet Peptides

Content Provider	Springer Nature Link
Author	Bourbo, Valery Matmor, Maayan Shtelman, Elina Rubiv, Boris Ashkenasy, Nurit Ashkenasy, Gonen
Copyright Year	2011
Abstract	Most self-replicating peptide systems are made of α-helix forming sequences. However, it has been postulated that shorter and simpler peptides may also serve as templates for replication when arranged into well-defined structures. We describe here the design and characterization of new peptides that form soluble β-sheet aggregates that serve to significantly accelerate their ligation and self-replication. We then discuss the relevance of these phenomena to early molecular evolution, in light of additional functionality associated with β-sheet assemblies.
Starting Page	563
Ending Page	567
Page Count	5
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	41
Issue Number	6
e-ISSN	15730875
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-12-03
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Prebiotic peptides Self-replication β-sheets Biochemistry Earth Sciences Astronomy, Observations and Techniques Life Sciences Astrophysics and Astroparticles
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

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Self-assembly and Self-replication of Short Amphiphilic β-sheet Peptides