NDLI: Toward Understanding Protocell Mechanosensation

Content Provider	Springer Nature Link
Author	Balleza, Daniel
Copyright Year	2010
Abstract	Mechanosensitive (MS) channels can prevent bacterial bursting during hypo-osmotic shocks by responding to increases in lateral tension at the membrane level through an integrated and coordinated opening mechanism. Mechanical regulation in protocells could have been one of the first mechanisms to evolve in order to preserve their integrity against changing environmental conditions. How has the rich functional diversity found in present cells been created throughout evolution, and what did the primordial MS channels look like? This review has been written with the aim of identifying which factors may have been important for the appearance of the first osmotic valve in a prebiotic context, and what this valve may have been like. It highlights the mechanical properties of lipid bilayers, the association of peptides as aggregates in membranes, and the conservation of sequence motifs as central aspects to understand the evolution of proteins that gate below the tension required for spontaneous pore formation and membrane rupture. The arguments developed here apply to both MscL and MscS homologs, but could be valid to mechano-susceptible proteins in general.
Starting Page	281
Ending Page	304
Page Count	24
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	41
Issue Number	3
e-ISSN	15730875
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-11-17
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Phospholipid membranes Prebiotic cells Peptides Osmotic valves Astronomy, Observations and Techniques Astrophysics and Astroparticles Biochemistry Earth Sciences Life Sciences
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

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