NDLI: Catalytic effects of Murchison Material: Prebiotic Synthesis and Degradation of RNA Precursors

Content Provider	Springer Nature Link
Author	Saladi, Raffaele Crestini, Claudia Cossetti, Cristina Mauro, Ernesto Deamer, David
Copyright Year	2011
Abstract	Mineral components of the Murchison meteorite were investigated in terms of potential catalytic effects on synthetic and hydrolytic reactions related to ribonucleic acid. We found that the mineral surfaces catalyzed condensation reactions of formamide to form carboxylic acids, amino acids, nucleobases and sugar precursors. These results suggest that formamide condensation reactions in the parent bodies of carbonaceous meteorites could give rise to multiple organic compounds thought to be required for the emergence of life. Previous studies have demonstrated similar catalytic effects for mineral assemblies likely to have been present in the early Earth environment. The minerals had little or no effect in promoting hydrolysis of RNA (24mer of polyadenylic acid) at 80°C over a pH range from 4.2 to 9.3. RNA was most stable in the neutral pH range, with a half-life ~5 h, but at higher and lower pH ranges the half-life decreased to ~1 h. These results suggest that if RNA was somehow incorporated into a primitive form of RNA-based thermophilic life, either it must be protected from random hydrolytic events, or the rate of synthesis must exceed the rate of hydrolysis.
Starting Page	437
Ending Page	451
Page Count	15
File Format	PDF
ISSN	01696149
Journal	Origins of Life and Evolution of Biospheres
Volume Number	41
Issue Number	5
e-ISSN	15730875
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-04-12
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Prebiotic chemistry Murchison meteorite Formamide Catalysis Life Sciences Astrophysics and Astroparticles Biochemistry Astronomy, Observations and Techniques Earth Sciences
Content Type	Text
Resource Type	Article
Subject	Medicine Ecology, Evolution, Behavior and Systematics Space and Planetary Science

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