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Increased Neuronal Nuclear Calcium Influx in Neonatal Seizures

Content Provider	Springer Nature Link
Author	Valencia, Ignacio Mishra, Om P. Fritz, Karen Zubrow, Alan Katsetos, Christos D. Delivoria Papadopoulos, Maria Legido, Agustín
Copyright Year	2006
Abstract	We hypothesized that neonatal seizures lead to increased Ca$^{2+}$ influx (nCa$^{2+}$I) in neuronal nuclei of newborn rats and that such increase is nitric-oxide mediated. Neuronal nuclear $^{45}$Ca$^{2+}$ influx (nCa$^{2+}$I) was measured in neuronal nuclei of 25 10-day-old male rat-pups newborn brains. They were divided into five groups (n = 5/group). (I) control; (II) hypoxia without seizures; (III) hypoxia with seizures; (IV) kainate, 2 mg/kg intraperitoneal (i.p.)-induced seizures and (V) 7-nitroindazole (7-NINA), 1 mg/kg i.p. pretreated, kainate-induced seizures. nCa$^{2+}$I was significantly (P < 0.05) increased following hypoxia or seizures (hypoxic- or kainate-induced). Post-hypoxic seizures further enhanced nCa$^{2+}$I increase induced by hypoxia (P < 0.05). 7-NINA abated the nCa$^{2+}$I increase induced by kainate. We conclude that (1) kainate or hypoxia-induced seizures in newborn rats modify the neuronal nuclear membrane function, resulting in increased nCa$^{2+}$I, (2) seizures exacerbate the hypoxia-induced increased nCa$^{2+}$I incurred after hypoxia and (3) intranuclear calcium surges during kainate-induced neonatal seizures are nitric oxide-mediated.
Starting Page	1231
Ending Page	1237
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	31
Issue Number	10
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2006-09-27
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neonatal seizures Status epilepticus Nuclear calcium influx Nitric oxide Neuronal damage Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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