NDLI: Beyond Polarity: Functional Membrane Domains in Astrocytes and Müller Cells

Content Provider	Springer Nature Link
Author	Derouiche, Amin Pannicke, Thomas Haseleu, Julia Blaess, Sandra Grosche, Jens Reichenbach, Andreas
Copyright Year	2012
Abstract	Various ependymoglial cells display varying degrees of process specialization, in particular processes contacting mesenchymal borders (pia, blood vessels, vitreous body), or those lining the ventricular surface. Within the neuropil, glial morphology, cellular contacts, and interaction partners are complex. It appears that glial processes contacting neurons, specific parts of neurons, or mesenchymal or ventricular borders are characterized by specialized membranes. We propose a concept of membrane domains in addition to the existing concept of ependymoglial polarity. Such membrane domains are equipped with certain membrane-bound proteins, enabling them to function in their specific environment. This review focuses on Müller cells and astrocytes and discusses exemplary the localization of established glial markers in membrane domains. We distinguish three functional glial membrane domains based on their typical molecular arrangement. The domain of the endfoot specifically displays the complex of dystrophin-associated proteins, aquaporin 4 and the potassium channel Kir4.1. We show that the domain of microvilli and the peripheral glial process in the Müller cell share the presence of ezrin, as do peripheral astrocyte processes. As a third domain, the Müller cell has peripheral glial processes related to a specific subtype of synapse. Although many details remain to be studied, the idea of glial membrane domains may permit new insights into glial function and pathology.
Starting Page	2513
Ending Page	2523
Page Count	11
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	37
Issue Number	11
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2012-06-24
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Endfoot processes Basal membrane Ezrin ERM proteins Aquaporins K$^{+}$ channels Biochemistry Neurochemistry Neurosciences Neurology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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