NDLI: The Expression Patterns of Nogo-A, Myelin Associated Glycoprotein and Oligodendrocyte Myelin Glycoprotein in the Retina After Ocular Hypertension : The Expression of Myelin Proteins in the Retina in Glaucoma

Content Provider	Springer Nature Link
Author	Liao, Xin Xue Chen, Dong Shi, Jianbo Sun, Yue Qi Sun, Shu Juan So, Kwok Fai Fu, Qing Ling
Copyright Year	2011
Abstract	Nogo-A, a major myelin inhibitory protein, inhibits axon growth and synaptic function in the central nervous system. Glaucoma is a progressive neuropathy as a result of retinal ganglion cell (RGC) death. Synaptic degeneration is thought to be an early pathology of neurodegeneration in glaucoma and precedes RGC loss. Here experimental ocular hypertension model was induced in adult rats with laser coagulation of the episcleral and limbal veins. The expression of Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp) in the retina was investigated using immunohistochemistry and Western blotting. We found that Nogo-A was expressed in the RGCs and upregulated after the induction of ocular hypertension. OMgp was only expressed in the inner plexiform layer. There was no MAG expression in the retina. Our data provided, for the first time, the expression patterns of three myelin proteins in the adult retina and suggested an important role of Nogo-A in the RGC death and synaptic degeneration in glaucoma.
Starting Page	1955
Ending Page	1961
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	36
Issue Number	11
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2011-06-04
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ocular hypertension Nogo-A Myelin-associated glycoprotein Oligodendrocyte myelin glycoprotein Retina Neurochemistry Neurosciences Neurology Cell Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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