NDLI: Heavy Metals Modulate Glutamatergic System in Human Platelets

Content Provider	Springer Nature Link
Author	Borges, V. C. Santos, F. W. Rocha, J. B. T. gueira, C. W.
Copyright Year	2007
Abstract	Research strategies have been developed to characterize parameters in peripheral tissues that might easily be measured in humans as surrogate markers of damage, dysfunction or interactions involving neural targets of toxicants. The similarities between platelet and neuron may even be clinically important, as a number of biochemical markers show parallel changes in the central nervous system (CNS) and platelets. The purpose of our research was to investigate the effect of Hg$^{2+}$, Pb$^{2+}$ and Cd$^{2+}$ on the [$^{3}$H]-glutamate binding and [$^{3}$H]-glutamate uptake in human platelets. The involvement of oxidative stress in the modulation of glutamatergic system induced by heavy metals was also investigated. The present study clearly demonstrates that Hg$^{2+}$, Cd$^{2+}$, and Pb$^{2+}$ inhibited [$^{3}$H]-glutamate uptake in human platelets. Hg$^{2+}$ inhibited [$^{3}$H]-glutamate binding, while Cd$^{2+}$ and Pb$^{2+}$ stimulated [$^{3}$H]-glutamate binding in human platelets. Hg$^{2+}$, Cd$^{2+}$ and Pb$^{2+}$ increased lipid peroxidation levels and reactive oxygen species (ROS) measurement in platelets. The present limited results could suggest that glutamatergic system may be used as a potential biomarker for neurotoxic action of heavy metals in humans.
Starting Page	953
Ending Page	958
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	32
Issue Number	6
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2007-04-04
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Platelets Heavy metals Glutamate binding Glutamate uptake SNC Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Organochalcogens Affect the Glutamatergic Neurotransmission in Human Platelets

Evidence that Hyperprolinemia Alters Glutamatergic Homeostasis in Rat Brain: Neuroprotector Effect of Guanosine

The neuroprotective effect of propofol against brain ischemia mediated by the glutamatergic signaling pathway in rats

Manganese Decreases Glutamate Uptake in Cultured Astrocytes

HCMV Induces Dysregulation of Glutamate Uptake and Transporter Expression in Human Fetal Astrocytes

Interaction Between Metals and Chelating Agents Affects Glutamate Binding on Brain Synaptic Membranes

Metabotropic Glutamate Receptors Modulate GABA Release from Mouse Hippocampal Slices

Diphenyl Diselenide-Induced Seizures in Rat Pups: Possible Interaction with Glutamatergic System

Metabotropic Glutamate Receptors Modulate Ischemia-Induced GABA Release in Mouse Hippocampal Slices

Heavy Metals Modulate Glutamatergic System in Human Platelets

Similar Documents

Organochalcogens Affect the Glutamatergic Neurotransmission in Human Platelets

Evidence that Hyperprolinemia Alters Glutamatergic Homeostasis in Rat Brain: Neuroprotector Effect of Guanosine

The neuroprotective effect of propofol against brain ischemia mediated by the glutamatergic signaling pathway in rats

Manganese Decreases Glutamate Uptake in Cultured Astrocytes

HCMV Induces Dysregulation of Glutamate Uptake and Transporter Expression in Human Fetal Astrocytes

Interaction Between Metals and Chelating Agents Affects Glutamate Binding on Brain Synaptic Membranes

Metabotropic Glutamate Receptors Modulate GABA Release from Mouse Hippocampal Slices

Diphenyl Diselenide-Induced Seizures in Rat Pups: Possible Interaction with Glutamatergic System

Metabotropic Glutamate Receptors Modulate Ischemia-Induced GABA Release in Mouse Hippocampal Slices

Heavy Metals Modulate Glutamatergic System in Human Platelets