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Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis

Content Provider	Springer Nature Link
Author	Zhang, Lihong Lü, Lanhai Chan, W. M. Huang, Yin Wai, Maria S. M. Yew, David T.
Copyright Year	2012
Abstract	3-n-Butylphthalide (NBP) is a compound extracted from Chinese celery and is used as an anti-hypertensive herbal medicine for treating stroke patients. The aim of this study is to demonstrate the effects and mechanisms of this compound through in vitro and in vivo experiments. Culture experiments were performed by adding hydrogen peroxide (H$_{2}$O$_{2}$) to SH-SY5Y cells. From the MTT assay result, enhanced cell survival was observed with DL-NBP treatment, regardless of whether they are added before, simultaneously with or after the addition of H$_{2}$O$_{2}$. For the in vivo experiment, Spontaneously Hypertensive rats and Wistar Kyoto control rats with chronic cerebral ischemia, which were induced by bilateral transection of the common carotid arteries, were given DL-NBP. Their performances in the place navigation test and spatial probe test in the Morris Water Maze have significantly improved compared with the DL-NBP untreated animals, indicating an improvement in spatial learning and memory in the ischemic-animals. In addition, in the chick embryonic chorioallantoic membrane assay, angiogenesis was more vigorous under the effects of DL-NBP, together with increased expression of growth factors, VEGF, VEGF-receptor and bFGF. All these suggested that one of the mechanisms of DL-NBP might be ameliorating vascular dementia and promoting angiogenesis.
Starting Page	911
Ending Page	919
Page Count	9
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	37
Issue Number	5
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2012-01-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	DL-3-n-Butylphthalide (NBP) Angiogenesis Vascular dementia Rats Culture Morris water maze Neurology Neurosciences Neurochemistry Cell Biology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis

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Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis