NDLI: Dl-3-n-butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF-κB signalling

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Dl-3-n-butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF-κB signalling

Content Provider	Scilit
Author	He, Zili Zhou, Yulong Lin, Li Wang, Qingqing Khor, Sinan Mao, Yuqin Li, Jiawei Zhen, Zengming Chen, Jian Gao, Zhenzhen Wu, Fenzan Zhang, Xie Zhang, Hongyu Xu, Hua-Zi Wang, Zhouguang Xiao, Jian
Copyright Year	2017
Description	Journal: Journal of Cellular and Molecular Medicine In this study, we examined the neuroprotective effects and anti‐inflammatory properties of Dl‐3‐n‐butylphthalide (NBP) in Sprague‐Dawley (SD) rats following traumatic spinal cord injury (SCI) as well as microglia activation and inflammatory response both in vivo and in vitro. Our results showed that NBP improved the locomotor recovery of SD rats after SCI an significantly diminished the lesion cavity area of the spinal cord, apoptotic activity in neurons, and the number of TUNEL‐positive cells at 7 days post‐injury. NBP inhibited activation of microglia, diminished the release of inflammatory mediators, and reduced the upregulation of microglial TLR4/NF‐κB expression at 1 day post‐injury. In a co‐culture system with BV‐2 cells and PC12 cells, NBP significantly reduced the cytotoxicity of BV‐2 cells following lipopolysaccharide (LPS) stimulation. In addition, NBP reduced the activation of BV‐2 cells, diminished the release of inflammatory mediators, and inhibited microglial TLR4/NF‐κB expression in BV‐2 cells. Our findings demonstrate that NBP may have neuroprotective and anti‐inflammatory properties in the treatment of SCI by inhibiting the activation of microglia via TLR4/NF‐κB signalling.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661102/pdf
Ending Page	3022
Page Count	13
Starting Page	3010
e-ISSN	15824934
DOI	10.1111/jcmm.13212
Journal	Journal of Cellular and Molecular Medicine
Issue Number	11
Volume Number	21
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-08-25
Access Restriction	Open
Subject Keyword	Journal: Journal of Cellular and Molecular Medicine Dl‐3‐n‐butylphthalide (nbp) Spinal Cord Injury
Content Type	Text
Resource Type	Article

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