NDLI: Prejunctional α$_{2}$-Adrenoceptors and Peroxide-Induced Potentiation of Norepinephrine Release from the Bovine Iris

Content Provider	Springer Nature Link
Author	Opere, Catherine A. Ohia, Sunny E.
Copyright Year	1998
Abstract	Peroxides can enhance field-stimulated [$^{3}$H]norepinephrine ([$^{3}$H]NE) release in isolated irides from several mammalian species. In the present study, we investigated the role of prejunctional α$_{2}$-adrenoceptors in peroxide-induced potentiation of sympathetic neurotransmission in bovine isolated irides. Isolated hemi-irides were incubated in a Krebs buffered-solution containing [$^{3}$H]NE and prepared for studies of neurotransmitter release using the superfusion method. α$_{2}$-Adrenoceptor agonists, oxymetazoline, UK-14304 and clonidine inhibited field-stimulated [$^{3}$H]NE overflow without affecting basal tritium efflux. Pretreatment of tissues with H$_{2}$O$_{2}$ (300 μM) had no effect on inhibition of evoked [$^{3}$H]NE release caused by the α$_{2}$-adrenergic agonists. However, H$_{2}$O$_{2}$ (300 μM) caused significant (P < 0.01) leftward shifts of excitatory concentration-response curves to yohimbine (10 nM–1 μM). In contrast, yohimbine (1 μM) did not prevent the enhancement of evoked [$^{3}$H]NE overflow induced by H$_{2}$O$_{2}$ (300 μM). In conclusion, excitatory effects of peroxides on sympathetic neurotransmission in bovine irides are not mediated by prejunctional α$_{2}$-adrenoceptors.
Starting Page	1093
Ending Page	1098
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	23
Issue Number	8
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1998-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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