NDLI: Hypoosmolarity Induces an Increase of Extracellular N-Acetylaspartate Concentration in the Rat Striatum

Content Provider	Springer Nature Link
Author	Davies, Siân E. C. Gotoh, Masaki Richards, Douglas A. Obrevitch, Tihomir P.
Copyright Year	1998
Abstract	We previously showed that extracellular levels of N-acetylaspartate (NAA) increase when a medium with reduced NaCl concentration is perfused through a microdialysis probe, and proposed that NAA may be released during hypoosmotic swelling. Here, we demonstrate that this effect is due to hypoosmolarity of the perfusion medium, and not to low NaCl. NAA changes in the dialysate were compared with those of taurine as the osmoregulatory role of this amino acid is established. Reduction of the NaCl concentration in the perfusion medium increased the dialysate levels of NAA and taurine, but this effect was abolished when NaCl was replaced by sucrose to maintain isosmolarity. The NAA response to hypoosmolarity was smaller than that of taurine, but it may still be important to neurons as NAA is predominantly neuronal in the mammalian CNS.
Starting Page	1021
Ending Page	1025
Page Count	5
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	23
Issue Number	8
e-ISSN	15736903
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1998-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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Hypoosmolarity Induces an Increase of Extracellular N-Acetylaspartate Concentration in the Rat Striatum