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Mephedrone and Nicotine: Oxidative Stress and Behavioral Interactions in Animal Models

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Mephedrone and Nicotine: Oxidative Stress and Behavioral Interactions in Animal Models

Content Provider	Springer Nature Link
Author	Budzynska, Barbara Boguszewska Czubara, Anna Kruk Slomka, Marta Kurzepa, Jacek Biala, Grazyna
Copyright Year	2015
Abstract	The purpose of our experiment was to examine the influence of co-administration of nicotine and mephedrone on anxiety-like behaviors, cognitive processes and the nicotine-induced behavioral sensitization as well as processes connected with induction of oxidative stress in the brain of male Swiss mice. The results revealed that co-administration of subthreshold doses of mephedrone and nicotine (0.05 mg/kg each) exerted marked anxiogenic profile in the elevated plus maze and displayed pro-cognitive action in the passive avoidance paradigm (nicotine 0.05 mg/kg and mephedrone 2.5 mg/kg). Furthermore, one of the main findings of the present study was that mephedrone, administered alone at the dose not affecting locomotor activity of mice (1 mg/kg), enhanced the expression of nicotine-induced locomotor sensitization. Moreover, mephedrone administered with nicotine decreased general antioxidant status and catalase activity as well as antioxidant enzymes activity in the hippocampus and prefrontal cortex and increased concentration of malondialdehyde, an indicator of lipid peroxidation processes. Considering the likelihood that mephedrone is taken as a part of polydrug combination with nicotine, the effects of this combination on mammalian organisms have been confirmed in our study. Understanding the consequences of co-administration of psychoactive substances on the central nervous system and oxidative processes in the brain provide the important toxicological significance, and may be useful in polydrug intoxication treatment.
Starting Page	1083
Ending Page	1093
Page Count	11
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	40
Issue Number	5
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2015-04-11
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mephedrone Nicotine Oxidative stress Memory Anxiety Locomotor sensitization Neurosciences Neurochemistry Biochemistry Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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Mephedrone and nicotine: oxidative stress and behavioral interactions in animal models.

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Mephedrone and Nicotine: Oxidative Stress and Behavioral Interactions in Animal Models