NDLI: Neuroprotective Effects of Ugonin K on Hydrogen Peroxide-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells

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Neuroprotective Effects of Ugonin K on Hydrogen Peroxide-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells

Content Provider	Springer Nature Link
Author	Lin, Yi Chien Huang, Yaun Chao Chen, Sheng Chih Liaw, Chih Chuang Kuo, Sheng Chu Huang, Li Jiau Gean, Po Wu
Copyright Year	2008
Abstract	Oxidative stress plays an important role in the pathological processes of various neurodegenerative diseases. Ugonin K, a flavonoid isolated from the rhizomes of Helminthostachys zeylanica, possesses potent antioxidant property. In this study, we investigate the neuroprotective effects of ugonin K on hydrogen peroxide (H$_{2}$O$_{2}$)-induced apoptosis in SH-SY5Y cells. Incubation of SH-SY5Y cells with H$_{2}$O$_{2}$ for 24 h induced cell death measured with MTT assay. Hoechst 33258 staining confirmed that the reduced cell viability by H$_{2}$O$_{2}$ was due to apoptosis. In addition, H$_{2}$O$_{2}$ increased the expression of 17-kDa cleaved fragment of caspase-3 which could be reversed by pretreatment with ugonin K. Pretreatment with ugonin K attenuated H$_{2}$O$_{2}$-induced cell death in a dose-dependent manner. Neuroprotective effect of ugonin K was abolished by ERK and PI3K inhibitors. Pretreatment with JNK kinase and p38 MAPK inhibitors had no effect on ugonin K-mediated protection against H$_{2}$O$_{2}$-induced apoptosis. Western blotting with anti-phospho-ERK1/2 and anti-phospho-Akt (pS473) antibodies showed that ugonin K increased both ERK1/2 and Akt phosphorylation. These results suggest that ugonin K by activation of ERK1/2 and PI3K/Akt signal pathways protects SH-SY5Y cells from H$_{2}$O$_{2}$-induced apoptosis.
Starting Page	923
Ending Page	930
Page Count	8
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	34
Issue Number	5
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2008-10-08
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Apoptosis Neuroprotection PI-3 kinase MAPK Hydrogen peroxide SH-SY5Y cells Neurology Biochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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