NDLI: Non-quantal secretion of acetylcholine from motor nerve endings: Molecular mechanisms, physiological role, and regulation

Please wait, while we are loading the content...

Contribution of GABA$_{A}$ receptor-mediated inhibition to the determination of the velocity tuning of low pass-tuned neurons of the Superior Colliculus

Key role of clathrin-mediated endocytosis in synaptic vesicle recycling

Disturbance of synaptic vesicle recycling resulting from deletion of a mammalian actin-binding protein, mAbp1

Changes in the mitochondrial permeability in medullary cardiovascular neurons influence the hemodynamics in rats

Transmission pathways in the rat superior cervical ganglion

Changes in the intracellular calcium concentration upon activation of rat superior cervical ganglion neurons

Involvement of L-type calcium channels and mitochondria in post-tetanic potentiation: Is it a general rule for different types of synapses?

NADPH-Diaphorase reactivity and neurovascular coupling in the basal forebrain and motor cortex

Effects of haloperidol, clotrimazole, and pyridoxal-5′-phosphate on synaptic transmission in smooth muscles of the human colon

Effects of haloperidol and clotrimazole on synaptic transmission in and contractile activity of smooth muscles of the guinea-pig intestine

Effect of B$_{1}$ hypovitaminosis on the efficacy of neuromuscular transmission in the murine diaphragm

Modulation of A-type potassium current in smooth-muscle cells of the rat Vas Deferens by Ca$^{2+}$/calmodulin-dependent protein kinase II

Neurophysiology : Volume 39, Issue 3, May 2007

Neurophysiology : Volume 39, Issue 2, March 2007

Neurophysiology : Volume 39, Issue 1, January 2007

Neurophysiology : Volume 38

Neurophysiology : Volume 37

Neurophysiology : Volume 36

Neurophysiology : Volume 35

Neurophysiology : Volume 34

Neurophysiology : Volume 33

Neurophysiology : Volume 32

Neurophysiology : Volume 31

Neurophysiology : Volume 30

Neurophysiology : Volume 29

Non-quantal secretion of acetylcholine from motor nerve endings: Molecular mechanisms, physiological role, and regulation

Content Provider	Springer Nature Link
Author	Malomouzh, A. I. Nikol’skii, E. E.
Copyright Year	2007
Abstract	Results of biochemical and electrophysiological experiments allowing researchers to identify non-quantal release of acetylcholine (ACh), in addition to quantal release, from motor nerve endings, are discussed in the lecture. Based on the analysis of our own data and publications of other experimenters on the dependence of non-quantal secretion on the composition of the ion milieu, sensitivity of this phenomenon to different physiologically active compounds, and peculiarities of its temperature dependence, the authors conclude that non-quantal secretion of the transmitter is an active transport process, and not a passive leakage of ACh from the cytoplasm of the nerve terminal. It is hypothesized that a high-affinity system of choline uptake can play the role of the ACh carrier through the presynaptic membrane. The involvement of non-quantal release in the control of electrogenesis in the muscle fiber and the relation between processes of quantal and non-quantal secretion of the transmitter providing adequate functioning of the nerve terminal in the resting state and in the course of long-lasting high-frequency rhythmic activity are described. Data on the ability of glutamate and nitric oxide to selectively modulate this type of neurosecretion are analyzed. The possible role of non-quantal secretion of ACh in pathogenesis of intoxications of ACh esterase is discussed.
Starting Page	307
Ending Page	317
Page Count	11
File Format	PDF
ISSN	00902977
Journal	Neurophysiology
Volume Number	39
Issue Number	4-5
e-ISSN	15739007
Language	English
Publisher	Springer US
Publisher Date	2007-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	neuromuscular synapse acetylcholine quantum of the transmitter non-quantal secretion of the transmitter H-reflex choline uptake system Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Purine P2Y receptors in ATP-mediated regulation of non-quantal acetylcholine release from motor nerve endings of rat diaphragm.

Fatty acids modulate transmitter release and functioning of potassium channels in motor nerve endings

Identification of the muscarinic receptor subtypes involved in autoregulation of acetylcholine quantal release from frog motor nerve endings.

Enhancement by carbachol of transmitter release from motor nerve terminals.

Acetylcholine-Induced Inhibition of Presynaptic Calcium Signals and Transmitter Release in the Frog Neuromuscular Junction

Dynamics of acetylcholine release in the frog neuromuscular junction during rhythmic stimulation and under choline deficiency

Bayesian analysis of the kinetics of quantal transmitter secretion at the neuromuscular junction

Reduction by intracellular calcium chelation of acetylcholine secretion without occluding the effects of adenosine at frog motor nerve endings.

Potentiating effect of allatostatin on transmitter quantal secretion in the mouse nerve-muscle synapse

Non-quantal secretion of acetylcholine from motor nerve endings: Molecular mechanisms, physiological role, and regulation

Similar Documents

Purine P2Y receptors in ATP-mediated regulation of non-quantal acetylcholine release from motor nerve endings of rat diaphragm.

Fatty acids modulate transmitter release and functioning of potassium channels in motor nerve endings

Identification of the muscarinic receptor subtypes involved in autoregulation of acetylcholine quantal release from frog motor nerve endings.

Enhancement by carbachol of transmitter release from motor nerve terminals.

Acetylcholine-Induced Inhibition of Presynaptic Calcium Signals and Transmitter Release in the Frog Neuromuscular Junction

Dynamics of acetylcholine release in the frog neuromuscular junction during rhythmic stimulation and under choline deficiency

Bayesian analysis of the kinetics of quantal transmitter secretion at the neuromuscular junction

Reduction by intracellular calcium chelation of acetylcholine secretion without occluding the effects of adenosine at frog motor nerve endings.

Potentiating effect of allatostatin on transmitter quantal secretion in the mouse nerve-muscle synapse

Non-quantal secretion of acetylcholine from motor nerve endings: Molecular mechanisms, physiological role, and regulation