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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Redman, R. S. Hunt, J. M. Silinsky, E. M. |
| Description | Author Affiliation: Hunt JM ( Department of Pharmacology, Northwestern University Medical School, Chicago, Illinois 60611.) |
| Abstract | 1. The calcium chelators bis-(aminophenoxy)ethane-tetraacetic acid (BAPTA) or dimethyl-BAPTA (DMBAPTA) were introduced into the cytoplasm of frog motor nerve endings by use of the AM loading technique. The effects of intracellular Ca2+ chelation was studied on quantal acetylcholine (ACh) release and on the action of adenosine. 2. Intracellular BAPTA or DMBAPTA prevented the increases in quantal ACh secretion normally evoked by caffeine. 3. Intracellular DMBAPTA decreased the number of ACh quanta released by individual nerve impulses and virtually eliminated the fast phase of facilitation in response to paired nerve impulses. 4. Adenosine reduced both spontaneous and evoked secretion of ACh quanta with its usual potency and efficacy in the presence of intracellular DMBAPTA. Adenosine had no significant effect on facilitation. 5. The results, which suggest that adenosine and intracellular DMBAPTA reduce ACh secretion by different mechanisms, are consistent with the hypothesis that adenosine inhibits ACh release by reducing the ability of Ca2+ to promote ACh secretion from frog motor nerve endings. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 3 |
| Volume Number | 111 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1994-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Acetylcholine Secretion Adenosine Pharmacology Calcium Metabolism Chelating Agents Egtazic Acid Analogs & Derivatives Motor Neurons Drug Effects Nerve Endings Animals Caffeine Physiology Cytoplasm Drug Interactions In Vitro Techniques Intracellular Fluid Neuromuscular Junction Rana Pipiens Research Support, U.S. Gov't, P.H.S. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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