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| Content Provider | Springer Nature Link |
|---|---|
| Author | Parani, Sundararajan Bupesh, Giridharan Manikandan, Elayaperumal Pandian, Kannaiyan Oluwafemi, Oluwatobi Samuel |
| Copyright Year | 2016 |
| Abstract | Water-soluble, mercaptosuccinic acid (MSA)-capped CdTe/CdS/ZnS core/double shell quantum dots (QDs) were prepared by successive growth of CdS and ZnS shells on the as-synthesized CdTe/CdS$_{thin}$ core/shell quantum dots. The formation of core/double shell structured QDs was investigated by ultraviolet-visible (UV–Vis) absorption and photoluminescence (PL) spectroscopy, PL decay studies, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The core/double shell QDs exhibited good photoluminescence quantum yield (PLQY) which is 70% higher than that of the parent core/shell QDs, and they are stable for months. The average particle size of the core/double shell QDs was ∼3 nm as calculated from the transmission electron microscope (TEM) images. The cytotoxicity of the QDs was evaluated on a variety of cancer cells such as HeLa, MCF-7, A549, and normal Vero cells by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) cell viability assay. The results showed that core/double shell QDs were less toxic to the cells when compared to the parent core/shell QDs. MCF-7 cells showed proliferation on incubation with QDs, and this is attributed to the metalloestrogenic activity of cadmium ions released from QDs. The core/double shell CdTe/CdS/ZnS (CSS) QDs were conjugated with transferrin and successfully employed for the biolabeling and fluorescent imaging of HeLa cells. These core/double shell QDs are highly promising fluorescent probe for cancer cell labeling and imaging applications. |
| Starting Page | 1 |
| Ending Page | 13 |
| Page Count | 13 |
| File Format | |
| ISSN | 13880764 |
| Journal | Journal of Nanoparticle Research |
| Volume Number | 18 |
| Issue Number | 11 |
| e-ISSN | 1572896X |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2016-11-21 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Quantum dots CdTe/CdS/ZnS Core/shell Cytotoxicity Cancer Metalloestrogen Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Lasers, Photonics, Optical Devices |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation |
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