NDLI: Cell viability and MRI performance of highly efficient polyol-coated magnetic nanoparticles

Content Provider	Springer Nature Link
Author	Arteaga Cardona, Fernando Gutiérrez García, Eric Hidalgo Tobón, Silvia López Vasquez, Ciro Brito Barrera, Yazmín A. Flores Tochihuitl, Julia Angulo Molina, Aracely Reyes Leyva, Julio R. González Rodríguez, Roberto Coffer, Jeffery L. Pal, Umapada Diaz Conti, Mario Pérez Peña Platas Neri, Diana Dies Suarez, Pilar Fonseca, Rebeca Sosa Arias Carrión, Oscar Méndez Rojas, Miguel A.
Copyright Year	2016
Abstract	This work aimed at determining conditions that would allow us to control the size of the NPs and create a system with characteristics apt for biomedical applications. We describe a comprehensive study on the synthesis and physical characterization of two highly sensitive sets of triethylene glycol (TREG) and polyethylene glycol (PEG)-coated superparamagnetic iron oxide nanoparticles (SPIONs) to be evaluated for use as magnetic resonance (MR) contrast agents. The ferrofluids demonstrated excellent colloidal stability in deionized water at pH 7.0 as indicated by dynamic light scattering (DLS) data. The magnetic relaxivities, r $_{2}$, were measured on a 1.5 T clinical MRI instrument. Values in the range from 205 to 257 mM$^{−1}$ s$^{−1}$ were obtained, varying proportionally to the SPIONs’ sizes and coating nature. Further in vitro cell viability tests and in vivo biodistribution analyses of the intravenously administered nanoparticles showed that the prepared systems have good biocompatibility and migrate to several organs, mainly the meninges, spleen, and liver. Based on these results, our findings demonstrated the potential utility of these nanosystems as clinical contrast agents for MR imaging.
Starting Page	1
Ending Page	16
Page Count	16
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	18
Issue Number	11
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-11-21
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Magnetite Nanoparticles MRI Relaxivity Cell viability Biodistribution Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Lasers, Photonics, Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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