NDLI: The euglobulin clot lysis time to assess the impact of nanoparticles on fibrinolysis

Content Provider	Springer Nature Link
Author	Minet, Valentine Alpan, Lutfiye Mullier, François Toussaint, Olivier Lucas, Stéphane Dogné, Jean Michel Laloy, Julie
Copyright Year	2015
Abstract	Nanoparticles (NPs) are developed for many applications in various fields, including nanomedicine. The NPs used in nanomedicine may disturb homeostasis in blood. Secondary hemostasis (blood coagulation) and fibrinolysis are complex physiological processes regulated by activators and inhibitors. An imbalance of this system can either lead to the development of hemorrhages or thrombosis. No data are currently available on the impact of NPs on fibrinolysis. The objectives of this study are (1) to select a screening test to study ex vivo the impact of NPs on fibrinolysis and (2) to test NPs with different physicochemical properties. Euglobulin clot lysis time test was selected to screen the impact of some NPs on fibrinolysis using normal pooled plasma. A dose-dependent decrease in the lysis time was observed with silicon dioxide and silver NPs without disturbing the fibrin network. Carbon black, silicon carbide, and copper oxide did not affect the lysis time at the tested concentrations.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	17
Issue Number	7
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-07-21
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nanoparticles Fibrinolysis Hemocompatibility Blood Nanomedicine Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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