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| Content Provider | Springer Nature Link |
|---|---|
| Author | Raţă, Delia Mihaela Chailan, Jean François Peptu, Cătălina Anişoara Costuleanu, Marcel Popa, Marcel |
| Copyright Year | 2015 |
| Abstract | This study reports the preparation of novel polymeric nanocapsules based on a natural polymer, chitosan and a synthetic one, poly(N-vinylpyrrolidone-alt-itaconic anhydride) [(poly(NVPAI)] using an interfacial condensation technique. The infrared spectroscopy studies confirmed the crosslinking through the presence of amide bonds, formed between the two polymers chains. The diameter of nanocapsules was found in the range of 126–214 nm and it was determined by dynamic light scattering method. Morphological characterization demonstrated their nano size, the spherical shape of the nanocapsules and the formation of hollow particles. The nanocapsules presented good swelling capacity in aqueous solutions. 5-Fluorouracil (5-FU) loading and release capacity was studied, the processes being controlled by the drug diffusion through the polymeric membrane. The obtained results were encouraging, showing that 5-FU-loaded nanocapsules had 70 % higher apoptotic effect on A549 tumour cells than the drug in free state or mixed with the nanocapsules. |
| Starting Page | 1 |
| Ending Page | 11 |
| Page Count | 11 |
| File Format | |
| ISSN | 13880764 |
| Journal | Journal of Nanoparticle Research |
| Volume Number | 17 |
| Issue Number | 7 |
| e-ISSN | 1572896X |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2015-07-21 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Polymeric nanocapsules Interfacial condensation 5-Fluorouracil Apoptotic effect Lung cancer Nanomedicine Health effects Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation |
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