NDLI: Fe$_{3}$O$_{4}$/Salicylic acid nanoparticles behavior on chick CAM vasculature

Content Provider	Springer Nature Link
Author	Mihaiescu, Dan Eduard Buteică, Alice Sandra Neamţu, Johny Istrati, Daniela Mîndrilă, Ion
Copyright Year	2013
Abstract	A modified ferrite co-precipitation synthesis was used to obtain core–shell Fe$_{3}$O$_{4}$/salicylic acid magnetic nanoparticles (Sa-MNP) with well-dispersed aqueous solution properties. The newly developed iron oxide nanoparticles properties were investigated with X-ray diffraction, Fourier transform infrared spectrometry, transmission electron microscopy, and laser light scattering for their characteristic establishment. The resulting Sa-MNPs have spherical morphology, homogenous size distribution around 60 nm (35 nm FWHM), and a 67 mV Zeta potential value (15.5 mV STDV). In vivo biocompatibility and intravascular behavior of the 60 nm diameter size range synthesized nanoparticles were evaluated on chick chorioallantoic membrane model. The results show a reversible and good controlled intravascular accumulation under static magnetic field, a low risk of embolisation with nanoparticle aggregates detached from venous intravascular nanoblocked areas, a persistent blocking of the arterioles and dependent capillaries network, a good circulating life time and biocompatibility. The beneficial effects of salicylic acid (SA) and in vivo demonstrated capacity of Sa-MNPs to cutoff regional vascular supply under static magnetic field control suggest a possible biomedical application of these MNPs in targeted cancer therapy through magnetic controlled blood flow nanoblocking mechanism.
Starting Page	1
Ending Page	10
Page Count	10
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	15
Issue Number	8
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-07-30
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Iron oxide nanoparticle Salicylic acid Chick CAM model Nanoblocker Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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