NDLI: Preparation and characterization of long-circulating PELMD/mPEG–PLGA-mixed micelles for 10-hydroxycamptothecin

Content Provider	Springer Nature Link
Author	Yin, Shaoping Li, Juan Li, Nannan Wang, Guangji Gu, Xiaochen
Copyright Year	2014
Abstract	A novel long-circulating nano-delivery system was constructed using block copolymers of poly monomethoxy-(ethylene glycol)-poly(d,l-lactic-co-glycolic acid)-poly(3(S)-methyl-morpholine-2,5-dione) (PELMD) and poly-monomethoxy (ethylene glycol)–poly-(d,l-lactic-co-glycolic acid) (mPEG–PLGA). The two copolymers possessed satisfactory critical micelle concentration and hemolytic effect. Antitumor compound 10-hydroxycamptothecin (HCPT) was loaded to the mixed micelles to further characterize in vitro and in vivo properties. HCPT-mixed micelles were measured 165–205 nm in particle size, with spherical core–shell structure and uniform-size distribution. The zeta potentials of the mixed micelles ranged 15–20 mV, attributed to the polydesipeptide. Stability of the mixed micelles was improved without complex synthesis. Drug release from the mixed micelles was pH-dependent, which was beneficial for improving specific drug targeting to tumor tissues. HCPT-mixed micelles demonstrated prolonged retention and tissue targeting in animal models. Mean residence time (MRT$_{0→∞}$) of HCPT-mixed micelles was significantly longer than that of HCPT injection, and biodistribution of the mixed micelles showed specific drug disposition in liver and lungs. The results indicated that PELMD/mPEG–PLGA-mixed micelles could become a potential drug delivery system for anticancer drugs to improve therapeutic efficacy and minimize adverse effects.
Starting Page	1
Ending Page	14
Page Count	14
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	16
Issue Number	2
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-01-29
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Amphiphilic block copolymers Mixed micelles Specific drug targeting Pharmacokinetics and distribution Cancer chemotherapy Nanomedicine Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

New amphiphilic PEG-b-P(ester–ether) micelles as potential drug nanocarriers

Applications of polymeric micelles with tumor targeted in chemotherapy

Peptide-conjugated micelles as a targeting nanocarrier for gene delivery

Magnetic core–bilayer shell complex of magnetite nanoparticle stabilized with mPEG–polyester amphiphilic block copolymer

Nanosuspensions of 10-hydroxycamptothecin that can maintain high and extended supersaturation to enhance oral absorption: preparation, characterization and in vitro/in vivo evaluation

Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery

Docetaxel grafted magnetic nanoparticles as dual-therapeutic agentia for targeting perfusion therapy of urethral carcinoma

Cationic nanoparticles with quaternary ammonium-functionalized PLGA–PEG-based copolymers for potent gene transfection

Dual drug-loaded paclitaxel–thymoquinone nanoparticles for effective breast cancer therapy

Preparation and characterization of long-circulating PELMD/mPEG–PLGA-mixed micelles for 10-hydroxycamptothecin

Similar Documents

New amphiphilic PEG-b-P(ester–ether) micelles as potential drug nanocarriers

Applications of polymeric micelles with tumor targeted in chemotherapy

Peptide-conjugated micelles as a targeting nanocarrier for gene delivery

Magnetic core–bilayer shell complex of magnetite nanoparticle stabilized with mPEG–polyester amphiphilic block copolymer

Nanosuspensions of 10-hydroxycamptothecin that can maintain high and extended supersaturation to enhance oral absorption: preparation, characterization and in vitro/in vivo evaluation

Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery

Docetaxel grafted magnetic nanoparticles as dual-therapeutic agentia for targeting perfusion therapy of urethral carcinoma

Cationic nanoparticles with quaternary ammonium-functionalized PLGA–PEG-based copolymers for potent gene transfection

Dual drug-loaded paclitaxel–thymoquinone nanoparticles for effective breast cancer therapy

Preparation and characterization of long-circulating PELMD/mPEG–PLGA-mixed micelles for 10-hydroxycamptothecin