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| Content Provider | Springer Nature Link |
|---|---|
| Author | Carvalhinho, Sara Costa, Ana Margarida Coelho, Ana Cláudia Martins, Eugénio Sampaio, Ana |
| Copyright Year | 2012 |
| Abstract | Forty Candida albicans strains isolated from patient’s mouth with fixed orthodontic appliances were analyzed to their susceptibilities to antifungal agents, mouth rinses and essential oils. Susceptibility to fluconazole, econazole, miconazole and ketoconazole, amphotericin B and nystatin was assessed by the disk diffusion (DD) method based on the Clinical and Laboratory Standards Institute M44-A protocol, and by Etest (fluconazole and amphotericin B). The susceptibilities to mouth rinses and essential oils were also determined by the DD technique. All isolates tested were susceptible (S) to amphotericin B, nystatin and fluconazole. The overall concordance between the DD and the Etest was 100% for amphotericin and fluconazole. One isolate was resistant to econazole (2.5%) and the other to ketoconazole (2.5%). Econazole and ketoconazole had the highest percentages of susceptible dose dependent (SDD), 55 and 95%, respectively. Regarding to the susceptibility isolates profile, seven phenotypes were detected, and the 3 more represented (90% of the isolates) of them were SDD to one, two or three azoles. The study of mouth rinses showed a high variability of efficacy against C. albicans. The results showed that the isolates susceptibility to essential oils differed (P < 0.05). The profile activity was: cinnamon > laurel > mint > eucalyptus > rosemary > lemon > myrrh > tangerine. The main finding was that the susceptibility to cinnamon and laurel varied among the three more representative antifungal phenotypes (P < 0.05). The susceptibility of econazole-SDD isolates to cinnamon and lemon was higher than those of the econazole-S yeasts (P < 0.05). In contrast, econazole-SDD isolates were less affected by laurel than econazole-S counterparts (P < 0.05). |
| Starting Page | 69 |
| Ending Page | 76 |
| Page Count | 8 |
| File Format | |
| ISSN | 0301486X |
| Journal | Mycopathologia |
| Volume Number | 174 |
| Issue Number | 1 |
| e-ISSN | 15730832 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2012-01-14 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Candida albicans Susceptibility Antifungal Essential oils Mouth rinses Plant Sciences Microbiology Microbial Ecology Medical Microbiology Eukaryotic Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Plant Science Veterinary Microbiology Applied Microbiology and Biotechnology Agronomy and Crop Science |
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