NDLI: Molecular Characterization and In Vitro Antifungal Susceptibility of 316 Clinical Isolates of Dermatophytes in Iran

Content Provider	Springer Nature Link
Author	Ansari, Saham Hedayati, Mohammad T. Zomorodian, Kamiar Pakshir, Keyvan Badali, Hamid Rafiei, Abdollah Ravandeh, Mostafa Seyedmousavi, Seyedmojtaba
Copyright Year	2015
Abstract	Dermatophytosis is a common mycotic infection of the skin, nail, and hair, associated with major public health concern worldwide. Various species of dermatophytes show significant differences in susceptibility to antifungals. Here, we present the antifungal susceptibility of a large collection of molecularly identified dermatophyte isolates obtained from tropical region of south of Iran. A total of 9485 patients clinically suspected to have cutaneous fungal infections were examined. Dermatophytosis was confirmed in 1502 cases by direct microscopy and culture. Three hundred and sixteen isolates recovered in culture were identified to species level using PCR sequencing of ITS region and RFLP. Tinea corporis was the most prevalent type of clinical manifestation (35.2 %), followed by tinea cruris (17 %), tinea capitis (12.8 %), tinea pedis (11.3 %), tinea manuum (11 %), tinea unguium (6.9 %), and tinea barbae (5.8 %). Trichophyton interdigitale was the most common isolate (49.36 %), followed by Trichophyton rubrum (18.98 %), Epidermophyton floccosum (13.29 %), Microsporum canis (9.17 %), Arthroderma benhamiae (T. anamorph of A. benhamiae; 5.38 %), and Trichophyton tonsurans (3.79 %). Overall, irrespective of the geographical region, terbinafine was the most potent antifungal against all isolates, with an MIC range of 0.002–0.25 μg/mL, followed by itraconazole (0.004–0.5 μg/mL), griseofulvin (0.125–8 μg/mL), and fluconazole (4–128 μg/mL). Analysis of our data revealed a significant increase in the frequency of A.benhamiae, which definitely warrants further investigation to explore source of this infection in south of Iran. Moreover, terbinafine was the most effective antifungal against all isolates, in vitro.
Starting Page	89
Ending Page	95
Page Count	7
File Format	PDF
ISSN	0301486X
Journal	Mycopathologia
Volume Number	181
Issue Number	1-2
e-ISSN	15730832
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-09-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dermatophytosis Molecular identification Antifungal susceptibility South of Iran Arthroderma benhamiae Microbiology Medical Microbiology Eukaryotic Microbiology Microbial Ecology Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Plant Science Veterinary Microbiology Applied Microbiology and Biotechnology Agronomy and Crop Science

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