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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kościuczuk, Ewa M. Lisowski, Paweł Jarczak, Justyna Strzałkowska, Nina Jóźwik, Artur Horbańczuk, Jarosław Krzyżewski, Józef Zwierzchowski, Lech Bagnicka, Emilia |
| Copyright Year | 2012 |
| Abstract | Cathelicidins are small, cationic, antimicrobial peptides found in humans and other species, including farm animals (cattle, horses, pigs, sheep, goats, chickens, rabbits and in some species of fish). These proteolytically activated peptides are part of the innate immune system of many vertebrates. These peptides show a broad spectrum of antimicrobial activity against bacteria, enveloped viruses and fungi. Apart from exerting direct antimicrobial effects, cathelicidins can also trigger specific defense responses in the host. Their roles in various pathophysiological conditions have been studied in mice and humans, but there are limited information about their expression sites and activities in livestock. The aim of the present review is to summarize current information about these antimicrobial peptides in farm animals, highlighting peptide expression sites, activities, and future applications for human and veterinary medicine. |
| Starting Page | 10957 |
| Ending Page | 10970 |
| Page Count | 14 |
| File Format | |
| ISSN | 03014851 |
| Journal | Molecular Biology Reports |
| Volume Number | 39 |
| Issue Number | 12 |
| e-ISSN | 15734978 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2012-10-14 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | AMP Cathelicidin Vertebrates Human Farm animals Activity Expression Animal Biochemistry Animal Anatomy / Morphology / Histology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Molecular Biology |
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