Please wait, while we are loading the content...
| Content Provider | Springer Nature Link |
|---|---|
| Author | Lee, Young Ho Bae, Sang Cheol Choi, Sung Jae Ji, Jong Dae Song, Gwan Gyu |
| Copyright Year | 2012 |
| Abstract | The aim of this study was to explore whether FAS −670 A/G and −1,377 G/A polymorphisms confer susceptibility to autoimmune rheumatic diseases. A meta-analysis was conducted on the associations between the FAS −670 A/G and −1,377 G/A polymorphisms and autoimmune rheumatic diseases using allele contrast, a recessive model, a dominant model, and an additive model. Thirteen articles with 21 comparison studies (16 on FAS −670 A/G and 5 on −1,377 G/A polymorphisms) including systemic lupus erythematosus (SLE), four systemic sclerosis, four Sjogren’s syndrome, three rheumatoid arthritis (RA), one juvenile idiopathic arthritis, and one spondyloarthropathy were available for the meta-analysis. Meta-analysis revealed an association between rheumatic diseases and the FAS −670 A/G polymorphism in the dominant model (odds ratio [OR] = 0.761, 95 % confidence interval [CI] = 0.621–0.932, p = 0.008]. Stratification by ethnicity indicated an association between the FAS −670 G allele carrier and rheumatic diseases in Asian (OR = 0.569, 95 % CI = 0.409–0.791, p = 0.001). Furthermore, stratification by disease indicated an association between the FAS −670 G allele carrier and SLE and RA (OR = 0.578, 95 % CI = 0.358–0.934, p = 0.025; OR = 0.609, 95 % CI = 0.398–0.934, p = 0.023, respectively). The FAS −670 G allele was negatively associated with SLE susceptibility. Meta-analysis of the FAS −1,377 G/A polymorphism stratified by disease showed an association between the FAS −1,377 A allele and SLE (OR = 0.783, 95 % CI = 0.613–0.997, p = 0.047). Meta-analyses using the dominant model also showed a significant association in SLE (OR = 0.712, 95 % CI = 0.528–0.961, p = 0.027). This meta-analysis demonstrates that the FAS −670 A/G polymorphism confers susceptibility to rheumatic diseases in Asians and SLE and RA, and the FAS −1,377 G/A polymorphism is associated with SLE susceptibility. |
| Starting Page | 10671 |
| Ending Page | 10679 |
| Page Count | 9 |
| File Format | |
| ISSN | 03014851 |
| Journal | Molecular Biology Reports |
| Volume Number | 39 |
| Issue Number | 12 |
| e-ISSN | 15734978 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2012-10-05 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | FAS Meta-analysis Polymorphism Rheumatic diseases Animal Biochemistry Animal Anatomy / Morphology / Histology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Molecular Biology |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|