NDLI: Investigation of the common paraoxonase 1 variants with paraoxonase activity on bone fragility in Turkish patients

Content Provider	Springer Nature Link
Author	Toptaş, Bahar Kurt, Özlem Aydoğan, Hülya Yılmaz Yaylim, Ilhan Zeybek, Ümit Can, Ayse Agachan, Bedia Uyar, Mehmet Özyavuz, M. Kerem İsbir, Turgay
Copyright Year	2013
Abstract	There is increasing evidence of a biochemical link between oxidative stress and bone metabolism. Oxidative stress has been shown to be involved in bone resorption as it causes loss of bone mineral density (BMD). Paraoxonase 1 (PON1), can prevent these effects of the oxidative stress on bone formation. It has been suggested that the PON1 gene as possibly implicated in reduced BMD in bone fragility cases. It has been hypothesized that PON1 gene polymorphisms may influence both the risk of osteoporosis and osteopenia occurrence and prognosis. The aim of our study is to evaluate the relationship between PON1 polymorphisms and bone fragility development. Seventy-four osteoporotic, 121 osteopenic and 79 nonosteoporotic postmenopausal women were recruited. For detection of the polymorphisms, polymerase chain reaction-restriction fragment length polymorphism techniques have been used. BMD was measured at the lumbar spine and hip by dual-energy X-ray absorptiometry. Distributions of PON1 (PON 192 and PON 55) polymorphisms in study groups were not significantly different. But, there was medium strength connection between in the osteopenic with control groups regarding PON1 55–PON1 192 haplotypes and we found a power strength connection between in the osteoporosis with control groups regarding PON1 55–PON1 192 haplotypes. Furthermore, subjects with PON1 192RR and PON1 55LL genotypes had lower PON activity values of osteoporotic subject compared to healthy control and this difference was statistically significant (p < 0.05). This result suggest that PON1 genotypes could be higher risk for osteoporosis, as determined by reduced BMD.
Starting Page	6519
Ending Page	6524
Page Count	6
File Format	PDF
ISSN	03014851
Journal	Molecular Biology Reports
Volume Number	40
Issue Number	11
e-ISSN	15734978
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-09-23
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Polymorphism Paraoxonase Osteoporosis Bone fragility PON1 Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association between paraoxonase-1 gene polymorphisms and risk of metabolic syndrome

Differential effects of paraoxonase 1 (PON1) polymorphisms on cancer risk: evidence from 25 published studies

Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma

R-carrying genotypes of serum paraoxonase (PON1) 192 polymorphism and higher activity ratio are related to susceptibility against ischemic stroke

Sequence identification, chromosomal mapping and tissue specific expression of the porcine paraoxonase 1 (PON1) gene

Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women

PON1 Q192R polymorphism (rs662) is associated with childhood embryonal tumors

The LOX-1 3′UTR188CT polymorphism and coronary artery disease in Turkish patients

Significant interethnic differencies in functional variants of PON1 and P2RY12 genes in Roma and Hungarian population samples

Investigation of the common paraoxonase 1 variants with paraoxonase activity on bone fragility in Turkish patients

Similar Documents

Association between paraoxonase-1 gene polymorphisms and risk of metabolic syndrome

Differential effects of paraoxonase 1 (PON1) polymorphisms on cancer risk: evidence from 25 published studies

Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma

R-carrying genotypes of serum paraoxonase (PON1) 192 polymorphism and higher activity ratio are related to susceptibility against ischemic stroke

Sequence identification, chromosomal mapping and tissue specific expression of the porcine paraoxonase 1 (PON1) gene

Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women

PON1 Q192R polymorphism (rs662) is associated with childhood embryonal tumors

The LOX-1 3′UTR188CT polymorphism and coronary artery disease in Turkish patients

Significant interethnic differencies in functional variants of PON1 and P2RY12 genes in Roma and Hungarian population samples

Investigation of the common paraoxonase 1 variants with paraoxonase activity on bone fragility in Turkish patients