NDLI: The activity of erythrocyte and brain Na$^{+}$/K$^{+}$ and Mg$^{2+}$-ATPases in rats subjected to acute homocysteine and homocysteine thiolactone administration

Content Provider	Springer Nature Link
Author	Rašić Marković, Aleksandra Stajlović, Olivera Hrnčić, Dragan Krstić, Danijela Čolović, Mirjana Šušić, Veselinka Radosavljević, Tatjana Djuric, Dragan
Copyright Year	2009
Abstract	Hyperhomocysteinemia is associated with various pathologies including cardiovascular disease, stroke, and cognitive dysfunctions. Systemic administration of homocysteine can trigger seizures in animals, and patients with homocystinuria suffer from epileptic seizures. Available data suggest that homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester. A number of reports have demonstrated a reduction of Na$^{+}$/K$^{+}$-ATPase activity in cerebral ischemia, epilepsy and neurodegeneration possibly associated with excitotoxic mechanisms. The aim of this study was to examine the in vivo effects of d,l-homocysteine and d,l-homocysteine thiolactone on Na$^{+}$/K$^{+}$- and Mg$^{2+}$-ATPase activities in erythrocyte (RBC), brain cortex, hippocampus, and brain stem of adult male rats. Our results demonstrate a moderate inhibition of rat hippocampal Na$^{+}$/K$^{+}$-ATPase activity by d,l-homocysteine, which however expressed no effect on the activity of this enzyme in the cortex and brain stem. In contrast,d,l-homocysteine thiolactone strongly inhibited Na$^{+}$/K$^{+}$-ATPase activity in cortex, hippocampus and brain stem of rats. RBC Na$^{+}$/K$^{+}$-ATPase and Mg$^{2+}$-ATPase activities were not affected by d,l-homocysteine, while d,l-homocysteine thiolactone inhibited only Na$^{+}$/K$^{+}$-ATPase activity. This study results show that homocysteine thiolactone significantly inhibits Na$^{+}$/K$^{+}$-ATPase activity in the cortex, hippocampus, and brain stem, which may contribute at least in part to the understanding of excitotoxic and convulsive properties of this substance.
Starting Page	39
Ending Page	45
Page Count	7
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	327
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2009-02-18
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Homocysteine Homocysteine thiolactone Na$^{+}$/K$^{+}$-ATPase Mg$^{2+}$-ATPase Erythrocyte Brain Rat Cardiology Oncology Medical Biochemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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