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| Content Provider | Springer Nature Link |
|---|---|
| Author | Mohanan, Valiya Veettil Chathu, Finla Paulose, Cheramadathikudyil S. |
| Copyright Year | 2005 |
| Abstract | The purpose of this study was to investigate the role of central 5-HT$_{2C}$ receptor binding in rat model of pancreatic regeneration using 60–70% pancreatectomy. The 5-HT and 5-HT$_{2C}$ receptor kinetics were studied in cerebral cortex and brain stem of sham operated, 72 h pancreatectomised and 7 days pancreatectomised rats. Scatchard analysis with [$^{3}$H] mesulergine in cerebral cortex showed a significant decrease (p < 0.05) in maximal binding (B$_{max}$) without any change in K$_{d}$ in 72 h pancreatectomised rats compared with sham. The decreased B$_{max}$ reversed to sham level by 7 days after pancreatectomy. In brain stem, Scatchard analysis showed a significant decrease (p < 0.01) in B$_{max}$ with a significant increase (p < 0.01) in K$_{d}$. Competition analysis in brain stem showed a shift in affinity towards a low affinity. These parameters were reversed to sham level by 7 days after pancreatectomy. Thus the results suggest that 5-HT through the 5-HT$_{2C}$ receptor in the brain has a functional regulatory role in the pancreatic regeneration. |
| Starting Page | 165 |
| Ending Page | 170 |
| Page Count | 6 |
| File Format | |
| ISSN | 03008177 |
| Journal | Molecular and Cellular Biochemistry |
| Volume Number | 272 |
| Issue Number | 1-2 |
| e-ISSN | 15734919 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2005-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | cerebral cortex brain stem 5-HT$_{2C}$ receptor pancreas regeneration Cardiology Medical Biochemistry Oncology Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Clinical Biochemistry Molecular Biology |
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