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| Content Provider | Springer Nature Link |
|---|---|
| Author | Popova, N. K. Naumenko, V. S. Kozhemyakina, R. V. Plyusnina, I. Z. |
| Copyright Year | 2010 |
| Abstract | The functional activity of serotonin 5-HT$_{2A}$ and 5-HT$_{2C}$ receptors and the expression of the genes encoding them were studied in Norway rats bred for 60 generations for the presence and absence of high levels of stress-evoked aggression to humans. There were no significant differences in the levels of 5-HT$_{2A}$ receptor mRNA in the midbrain, frontal cortex, and hippocampus and the extents of head twitching evoked by the 5-HT$_{2A}$ agonist DOI in rats with and without genetically determined high levels of aggression. Administration of the selective 5-HT$_{2C}$ agonist MK-212 weakened reflex startle in response to an acoustic signal (the acoustic startle response) in non-aggressive animals but had no significant effects on the response in aggressive animals. Increases in the level of 5-HT$_{2C}$ receptor mRNA were seen in the frontal cortex and hippocampus in non-aggressive rats as compared with aggressive animals. Increases in the expression of the 5-HT$_{2C}$ receptor gene and the functional state of 5-HT$_{2C}$ receptors were seen in the brains of non-aggressive rats, without any changes in the 5-HT$_{2A}$ receptor mRNA level or receptor sensitivity; this is evidence for the involvement of 5-HT$_{2C}$ receptors in the mechanisms inhibiting fear-evoked aggressive behavior. |
| Starting Page | 357 |
| Ending Page | 361 |
| Page Count | 5 |
| File Format | |
| ISSN | 00970549 |
| Journal | Neuroscience and Behavioral Physiology |
| Volume Number | 40 |
| Issue Number | 4 |
| e-ISSN | 1573899X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2010-03-25 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | serotonin aggression 5-HT$_{2A}$ receptors 5-HT$_{2C}$ receptors functional activity gene expression Behavioural Sciences Neurobiology Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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