NDLI: Natural vanadium-containing Mt. Fuji ground water improves hypo-activity of liver insulin receptor in Goto-Kakisaki rats

Content Provider	Springer Nature Link
Author	Kato, Katsuhiko Yamada, Shizuo Ohmori, Yuki Oki, Tomomi Kawamoto, Eiichi Shirama, Kazuhiko Watanabe, Yasuo
Copyright Year	2004
Abstract	After daily treatments with Mt. Fuji ground water containing natural vanadium (approximately 65 μg/l) at doses of 0.53 μg/kg/day for 12 weeks, blood glucose (BG), serum hemoglobin A1C (HbA1C) levels and insulin secretion from the pancreas of Goto-Kakisaki (GK) rats, a genetic model of Type 2 diabetes, were improved. In GK rat liver insulin receptors, the binding properties of [$^{125}$I] insulin, and the activities of insulin receptor β subunit and primary insulin-like growth factor-1β all recovered to normal levels of those found in Wistar rats. These results suggest that daily treatment with small concentrations of natural vanadium improves hyperglycemia by ameliorating liver insulin receptor activity. (Mol Cell Biochem 267: 203–207, 2004)
Starting Page	203
Ending Page	207
Page Count	5
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	267
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiology Medical Biochemistry Oncology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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Natural vanadium-containing Mt. Fuji ground water improves hypo-activity of liver insulin receptor in Goto-Kakisaki rats