NDLI: Iron promotes cadmium binding to citrate

Content Provider	Springer Nature Link
Author	Martinez, R. Brassard, P. Mwanjewe, J. Grover, A.K.
Copyright Year	2001
Abstract	Iron‐cadmium interactions are important in cadmium toxicity. Dietary iron supplements may decrease cadmium retention after oral cadmium exposure but the underlying mechanism is not known. Using a CdS/AgS ion selective electrode to measure [Cd$^{2+}$] in physiological saline solution at pH 7.4, we show that Fe$^{2+}$ promotes Cd$^{2+}$ binding to citrate thereby decreasing the availability of free Cd$^{2+}$. This suggests the formation of high molecular weight Cd$^{2+}$‐Fe$^{2+}$‐citrate complexes. We confirm this suggestion by showing that $^{109}$Cd$^{2+}$ is retained by 1 kDa cut off filters when present with total 50 μM Fe$^{2+}$ plus 1 mM citrate but not when present with citrate alone. The formation of high molecular weight complexes may prevent Cd$^{2+}$ absorption. As citrate is part of the diet, we suggest that these iron‐cadmium interactions may contribute to the protective effect of iron against cadmium toxicity.
Starting Page	93
Ending Page	96
Page Count	4
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	225
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2001-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiology Medical Biochemistry Oncology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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