NDLI: Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines

Content Provider	Springer Nature Link
Author	Lescoat, Gérard Gouffier, Lucie Cannie, Isabelle Lowe, Olive Morel, Isabelle Lepage, Sylvie Ropert, Martine Loréal, Olivier Brissot, Pierre Gaboriau, François
Copyright Year	2013
Abstract	Natural polyamines such as putrescine (Put), spermidine (Spd), and spermine (Spm), which are present in the human diet in large amounts, associated with their active transporter, are assumed to play a role in non-heme iron uptake and iron bioavailability from nutrients. Enterocytes and hepatocytes play pivotal roles in the regulation of body iron homeostasis. In this study, we report the effects of natural polyamines on iron transport in the Caco-2 cell line. In enterocyte-like Caco-2 cells, polyamines did not significantly modulate the transepithelial iron flux across the cell monolayer cultured on permeable membranes. In contrast, Spd, Spm, and to a lesser extent, Put were shown to activate Caco-2 cell iron uptake and to induce an increase in the ferritin level. This iron co-transport in enterocytes, which involved an interaction between iron and polyamine then cell uptake of the polyamine–iron complexes by the polyamine transport system, was more pronounced in proliferating than in differentiated Caco-2 cells. Moreover, it was observed at physiological concentrations of both polyamines and iron. It could thus play a role in the rapid renewal of enterocytes. These data suggest the involvement of polyamines as components of the pool of transferrin-independent iron-chelating vectors. Further investigations are needed to demonstrate their biological relevance in physiological situations.
Starting Page	205
Ending Page	215
Page Count	11
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	378
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2013-03-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Iron transport Polyamines Enterocytes Caco-2 cell line Cell proliferation Biochemistry Medical Biochemistry Oncology Cardiology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Isothiocyanate–drug interactions in the human adenocarcinoma cell line Caco-2

MAP kinases in proliferating human colon cancer Caco-2 cells

Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells

Involvement of GPR12 in the regulation of cell proliferation and survival

Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells

Histidine and histamine metabolism in rat enterocytes

Cell line dependent involvement of ceramide in ultraviolet light-induced apoptosis

Docosahexaenoic acid and eicosapentaenoic acid-enriched phosphatidylcholine liposomes enhance the permeability, transportation and uptake of phospholipids in Caco-2 cells

Transport kinetics of zinc, copper, selenium, and iron in perfused human placental lobule in vitro

Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines

Similar Documents

Isothiocyanate–drug interactions in the human adenocarcinoma cell line Caco-2

MAP kinases in proliferating human colon cancer Caco-2 cells

Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells

Involvement of GPR12 in the regulation of cell proliferation and survival

Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells

Histidine and histamine metabolism in rat enterocytes

Cell line dependent involvement of ceramide in ultraviolet light-induced apoptosis

Docosahexaenoic acid and eicosapentaenoic acid-enriched phosphatidylcholine liposomes enhance the permeability, transportation and uptake of phospholipids in Caco-2 cells

Transport kinetics of zinc, copper, selenium, and iron in perfused human placental lobule in vitro

Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines