NDLI: The progressive effects of a fat enriched diet on ventricular myocyte contraction and intracellular Ca$^{2+}$ in the C57BL/6J mouse

Content Provider	Springer Nature Link
Author	Howarth, F. C. Qureshi, M. A. Gbewonyo, A. J. Tariq, S. Adeghate, E.
Copyright Year	2005
Abstract	The C57BL/6J mouse has a genetic susceptibility to develop diabetes when fed with a high-fat, high-sucrose diet. The general characteristics of diet-induced diabetes in this model include progressive development of hyperinsulinaemia, hyperglycaemia, insulin resistance and obesity, features that are frequently observed in the clinical setting. This study investigated the progressive effects of a fat enriched (FE) diet on contraction and intracellular Ca$^{2+}$ in ventricular myocytes from the C57BL/6J mouse. The characteristics of the mice fed with the FE diet compared to mice receiving control diet included progressive increase in the rate of body weight gain, increased fasting blood glucose and time-dependent differences in the disposal of blood glucose after a glucose challenge. The ultrastructure of cardiac myocytes and associated capillaries did not show any gross morphological alteration after 27 weeks of FE diet compared to controls.At 5 months the resting cell length (RCL) and the kinetics of shortening were not significantly altered in ventricular myocytes from mice receiving the FE diet compared to age-matched controls. At 5 and at 7 months the amplitude of shortening was increased in myocytes receiving the FED diet compared to controls. At 7 months the time to half (THALF) relaxation of myocyte contraction was shortened in myocytes from mice receiving the FE diet compared to controls. Mean THALF relaxation in myocytes from mice fed the FE diet was 32.0 ± 1.4 ms (n = 23) compared to 40.2 ± 2.0 ms (n = 27) in controls. Neither resting intracellular Ca$^{2+}$ nor the kinetics or amplitude of the Ca$^{2+}$ transient were altered by FE diet. Differences in myofilament sensitivity to Ca$^{2+}$ might underlie the changes in contractility.
Starting Page	87
Ending Page	95
Page Count	9
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	273
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	contraction diabetes mellitus diet heart intracellular calcium ventricular myocytes Cardiology Medical Biochemistry Oncology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The chronic effects of neonatal alloxan-induced diabetes mellitus on ventricular myocyte shortening and cytosolic Ca$^{2+}$

Alloxan reduces amplitude of ventricular myocyte shortening and intracellular Ca$^{2+}$ without altering L-type Ca$^{2+}$ current, sarcoplasmic reticulum Ca$^{2+}$ content or myofilament sensitivity to Ca$^{2+}$ in Wistar rats

Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca$^{2+}$ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart

Effects of single high-dose and multiple low-dose streptozotocin on contraction and intracellular Ca$^{2+}$ in ventricular myocytes from diabetes resistant and susceptible rats

Antihyperglycemic effect of carvacrol in combination with rosiglitazone in high-fat diet-induced type 2 diabetic C57BL/6J mice

Effects of varying intensity exercise on shortening and intracellular calcium in ventricular myocytes from streptozotocin (STZ)-induced diabetic rats

Myofilament sensitivity to Ca$^{2+}$ in ventricular myocytes from the Goto–Kakizaki diabetic rat

Presence of store-operated $Ca^{2+}$ entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane

Effects of acidosis on ventricular myocyte shortening and intracellular Ca$^{2+}$ in streptozotocin-induced diabetic rats

The progressive effects of a fat enriched diet on ventricular myocyte contraction and intracellular Ca$^{2+}$ in the C57BL/6J mouse

Similar Documents

The chronic effects of neonatal alloxan-induced diabetes mellitus on ventricular myocyte shortening and cytosolic Ca$^{2+}$

Alloxan reduces amplitude of ventricular myocyte shortening and intracellular Ca$^{2+}$ without altering L-type Ca$^{2+}$ current, sarcoplasmic reticulum Ca$^{2+}$ content or myofilament sensitivity to Ca$^{2+}$ in Wistar rats

Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca$^{2+}$ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart

Effects of single high-dose and multiple low-dose streptozotocin on contraction and intracellular Ca$^{2+}$ in ventricular myocytes from diabetes resistant and susceptible rats

Antihyperglycemic effect of carvacrol in combination with rosiglitazone in high-fat diet-induced type 2 diabetic C57BL/6J mice

Effects of varying intensity exercise on shortening and intracellular calcium in ventricular myocytes from streptozotocin (STZ)-induced diabetic rats

Myofilament sensitivity to Ca$^{2+}$ in ventricular myocytes from the Goto–Kakizaki diabetic rat

Presence of store-operated $Ca^{2+}$ entry in C57BL/6J mouse ventricular myocytes and its suppression by sevoflurane

Effects of acidosis on ventricular myocyte shortening and intracellular Ca$^{2+}$ in streptozotocin-induced diabetic rats

The progressive effects of a fat enriched diet on ventricular myocyte contraction and intracellular Ca$^{2+}$ in the C57BL/6J mouse