NDLI: Spontaneous skin damage and delayed wound healing in SOD1-deficient mice

Content Provider	Springer Nature Link
Author	Iuchi, Yoshihito Roy, Dipa Okada, Futoshi Kibe, riko Tsuda, Satoshi Suzuki, Saori Takahashi, Motoko Yokoyama, Hidekatsu Yoshitake, Jun Kondo, Seiji Fujii, Junichi
Copyright Year	2010
Abstract	Superoxide dismutase 1 (SOD1) is an important antioxidative enzyme that protects skin from oxidative stress. SOD1 $^{−/−}$ mice with a genetic background of b129Sv mice showed facial skin damage after 15 weeks of age. Eyelid swelling occurred as the initial symptom and caused impairment by triggering self-scratching. The period required for wound healing in the back was markedly delayed in 20-week SOD1 $^{−/−}$ mice. Oxidative stress markers, 4-hydroxynonenal and thiobarbituric acid-reactive substances, were unexpectedly lower in SOD1 $^{−/−}$ mice at day 1 after wounding. The decay rate of electron paramagnetic resonance signal intensity of intravenously injected nitroxide radical indicated that the half-life of the signal intensity was significantly prolonged in the wounded skin of SOD1 $^{+/+}$ mice. However, while the half-life of the signal intensity in control skin was a little longer in SOD1 $^{−/−}$ mice, it did not change in wounded skin. Taken together, these data suggest that the skin of SOD1 $^{−/−}$ mice is in redox imbalance and prone to damage by wounding.
Starting Page	181
Ending Page	194
Page Count	14
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	341
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2010-03-30
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Superoxide dismutase Wound healing Electron paramagnetic resonance Redox status Skin Cardiology Oncology Medical Biochemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effect of Dehydrozingerone, a half analog of curcumin on dexamethasone-delayed wound healing in albino rats

Electron paramagnetic resonance imaging of nitric oxide organ distribution in lipopolysuccaride treated mice

Electron Paramagnetic Resonance Studies of Cobalt-Copper Bovine Superoxide Dismutase

Novel Mutations that Enhance or Repress the Aggregation Potential of SOD1

Antioxidant status during cutaneous wound healing in immunocompromised rats

Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein gene

Erythrocyte Oxidant/Antioxidant Status in Essential Hyperhidrosis

Yeast Lacking Superoxide Dismutase(s) Show Elevated Levels of “Free Iron” as Measured by Whole Cell Electron Paramagnetic Resonance

Alterations in the expression of genes related to NF-κB signaling in liver and kidney of CuZnSOD-deficient mice

Spontaneous skin damage and delayed wound healing in SOD1-deficient mice

Similar Documents

Effect of Dehydrozingerone, a half analog of curcumin on dexamethasone-delayed wound healing in albino rats

Electron paramagnetic resonance imaging of nitric oxide organ distribution in lipopolysuccaride treated mice

Electron Paramagnetic Resonance Studies of Cobalt-Copper Bovine Superoxide Dismutase

Novel Mutations that Enhance or Repress the Aggregation Potential of SOD1

Antioxidant status during cutaneous wound healing in immunocompromised rats

Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein gene

Erythrocyte Oxidant/Antioxidant Status in Essential Hyperhidrosis

Yeast Lacking Superoxide Dismutase(s) Show Elevated Levels of “Free Iron” as Measured by Whole Cell Electron Paramagnetic Resonance

Alterations in the expression of genes related to NF-κB signaling in liver and kidney of CuZnSOD-deficient mice

Spontaneous skin damage and delayed wound healing in SOD1-deficient mice