NDLI: Arf6, RalA, and BIRC5 protein expression in nonsmall cell lung cancer

Content Provider	Springer Nature Link
Author	Knizhnik, A. V. Kovaleva, O. V. Laktiov, K. K. Mochalnikova, V. V. Komelkov, A. V. Tchevkina, E. M. Zborovskaya, I. B.
Copyright Year	2011
Abstract	Evaluation of tumor marker expression pattern that determines individual progression parameters is one of the major topics in molecular oncopathology research. This work represents research on expression analysis of several Ras-Ral associated signal transduction pathway proteins (Arf6, RalA, and BIRC5) in accordance with clinical criteria in nonsmall cell lung cancer patients. Using Western-blot analysis and RT-PCR Arf6, RalA, and BIRC5, expression has been analyzed in 53 nonsmall cell lung cancer samples of different origin. Arf6 protein expression was increased in 55% nonsmall cell lung cancer tumor samples in comparison with normal tissue. In the group of squamous cell lung cancer, increase of Arf6 expression was observed more often. RalA protein expression was decreased in comparison to normal tissue samples in 64% of nonsmall cell lung cancer regardless of morphological structure. Correlation between the decrease of RalA protein expression and the absence of regional metastases was revealed for squamous cell lung cancer. BIRC5 protein expression in tumor samples versus corresponding normal tissue was 1.3 times more often elevated in the squamous cell lung cancer group (in 76% tumor samples). At the same time, increase of BIRC5 expression was detected only in 63% of adenocarcinoma tumor samples. A statistically significant decrease (p = 0.015) of RalA protein expression and the increase (p = 0.049) of Arf6 protein expression in comparison with normal tissue was found in T$_{1–2}$N$_{0}$M$_{0}$ and T$_{1–2}$N$_{1–2}$M$_{0}$ groups of squamous cell lung cancer, respectively.
Starting Page	275
Ending Page	282
Page Count	8
File Format	PDF
ISSN	00268933
Journal	Molecular Biology
Volume Number	45
Issue Number	2
e-ISSN	16083245
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2011-04-26
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	squamous cell lung cancer nonsmall cell lung cancer adenocarcinoma RalA Arf6 BIRC5 survivin Human Genetics Biochemistry Life Sciences
Content Type	Text
Resource Type	Article
Subject	Structural Biology Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Increased expression of BIRC5 in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with the expression of its inhibitors SMAC/DIABLO and PML

Decreased expression of the human immunoglobulin J-chain gene in squamous cell cancer and adenocarcinoma of the lungs

Prediction of nonsmall cell lung cancer sensitivity to cisplastin and paclitaxel based on marker gene expression

Transcription of TIMP3, DAPK1, and AKR1B10 in squamous-cell lung cancer

Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer

Analysis of tissue-specific differentially methylated genes with differential gene expression in non-small cell lung cancers

Downregulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1, and HYAL2 in non-small cell lung cancer

RPN1, a new reference gene for quantitative data normalization in lung and kidney cancer

RASSF1A expression level in primary epithelial tumors of various locations

Arf6, RalA, and BIRC5 protein expression in nonsmall cell lung cancer

Similar Documents

Increased expression of BIRC5 in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with the expression of its inhibitors SMAC/DIABLO and PML

Decreased expression of the human immunoglobulin J-chain gene in squamous cell cancer and adenocarcinoma of the lungs

Prediction of nonsmall cell lung cancer sensitivity to cisplastin and paclitaxel based on marker gene expression

Transcription of TIMP3, DAPK1, and AKR1B10 in squamous-cell lung cancer

Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer

Analysis of tissue-specific differentially methylated genes with differential gene expression in non-small cell lung cancers

Downregulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1, and HYAL2 in non-small cell lung cancer

RPN1, a new reference gene for quantitative data normalization in lung and kidney cancer

RASSF1A expression level in primary epithelial tumors of various locations

Arf6, RalA, and BIRC5 protein expression in nonsmall cell lung cancer