NDLI: Structure and function of histone chaperone FACT

Content Provider	Springer Nature Link
Author	Bondarenko, M. T. Maluchenko, N. V. Valieva, M. E. Gerasimova, N. S. Kulaeva, O. I. Georgiev, P. G. Studitsky, V. M.
Copyright Year	2015
Abstract	FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying the chromatin structure during various DNA-dependent processes. FACT is involved in nucleosome assembly de novo and in the preservation and recovery of the nucleosome structure during and after transcription, replication and DNA repair. During transcript elongation, FACT reduces the height of the nucleosome barrier and supports the maintenance of nucleosomes during and after the passage of RNA polymerase II. In this process, FACT interacts with histone H2A–H2B dimer within nucleosomes, thus, facilitating uncoiling of nucleosomal DNA from the octamer of histones. It also facilitates the subsequent recovery of the canonical nucleosome structure after transcription. FACT also plays an important role in the transformation of human cells and in maintaining the viability of tumor cells.
Starting Page	796
Ending Page	809
Page Count	14
File Format	PDF
ISSN	00268933
Journal	Molecular Biology
Volume Number	49
Issue Number	6
e-ISSN	16083245
Language	English
Publisher	Pleiades Publishing
Publisher Date	2015-12-11
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	FACT transcription chromatin histones H2A–H2B Life Sciences Biochemistry Human Genetics
Content Type	Text
Resource Type	Book Review
Subject	Structural Biology Biophysics

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