NDLI: A comparative analysis of various antigenic proteins found in Haemonchus contortus

Content Provider	Springer Nature Link
Author	Tak, I. R. Dar, J. S. Dar, S. A. Ganai, B. A. Chishti, M. Z. Ahmad, F.
Copyright Year	2015
Abstract	Many innovative researches on the development and introduction of recombinant vaccines against many economically important parasites were carried out in the 20th century. Research continues to hold promise with the development of immunological and molecular approaches for control of these parasites and in this regard it has already been seen that blood-sucking parasites such as Haemonchus contortus and Ostertagia ostertagi are susceptible to control by vaccines containing “novel” or “concealed” antigens. Haemonchus contortus is primarily pathogenic to sheep and its blood-feeding behaviour causes effects ranging from mild anaemia to mortality in young animals. Current means of control which are dependent on repeated treatment with anthelmintics are responsible for the increasing drug resistance of this parasite. Together with the growing concern of residual chemicals in the environment and food chain, this has led to attempts to better understand the biology of the parasite with an aim to develop alternate means of control, including the development of molecular vaccines. More problematic and also important is the formulation and delivery strategy to induce expulsion of this parasite, using vaccines containing recombinant “conventional” antigens. Tremendous progress has been made in the last decade in identifying several antigens from Haemonchus contortus which in their native form stimulate useful levels of protective immunity. Vaccines have been developed against H. contortus using ‘novel’ gut antigens from the parasite, but variable responsiveness of the host sheep has resulted in varying degrees of protection which are stimulated by these vaccines. Computer models have also been used to simulate vaccine efficacy in worm control and have yielded good results. This review will try to summarise the protective efficacy and also the molecular properties of principal candidate antigens which are expressed by this parasite. The review will try to cover the aspirations, current success, limitations and problems faced by researchers in the control of this economically important parasite.
Starting Page	789
Ending Page	795
Page Count	7
File Format	PDF
ISSN	00268933
Journal	Molecular Biology
Volume Number	49
Issue Number	6
e-ISSN	16083245
Language	English
Publisher	Pleiades Publishing
Publisher Date	2015-12-11
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Haemonchus contortus Ostertagia ostertagi vaccines anthelmintics sheep Life Sciences Biochemistry Human Genetics
Content Type	Text
Resource Type	Book Review
Subject	Structural Biology Biophysics

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