NDLI: Design and development of pH-sensitive liposomes by evaluating the thermotropic behavior of their chimeric bilayers

Content Provider	Springer Nature Link
Author	Kyrili, Aimilia Chountoulesi, Maria Pippa, Natassa Meristoudi, Anastasia Pispas, Stergios Demetzos, Costas
Copyright Year	2017
Abstract	This study is focused on mixed/chimeric advanced drug delivery nanosystems and specifically on pH-sensitive liposomes, combining lipids and pH-responsive amphiphilic block copolymers. Chimeric liposomes are composed of hydrogenated soy phosphatidylcholine (HSPC) and two different poly(n-butylacrylate)-b-poly(acrylic acid) (PnBA-b-PAA) block copolymers with 85 and 70% content of PAA, at six different molar ratios. PAA block exhibits pH responsiveness, because of the regulative group of –COOH. Chimeric bilayers are composed of HSPC and PnBA-b-PAA. Experiments are carried out by using differential scanning calorimetry (DSC) in order to investigate their thermotropic properties. DSC indicated disappearance of the pretransition effect in all chimeric lipid bilayers, at both buffers [phosphate buffer saline (PBS) and citrate buffer], and slight changes of the main transition temperature (T $_{m}$). Contrariwise, the cooperativity (T $_{1/2}$) presented alterations between the two different buffers. Chimeric liposomes have been prepared and their physicochemical characteristics have been explored in PBS and citrate buffer by measuring the size, size distribution and ζ-potential. Liposomes are found to retain the mean value of their size during the stability studies. The physicochemical characteristics and the stability assessment of chimeric liposomes are correlated with DSC measurements of mixed bilayers. The incorporation of the appropriate amount of these novel pH-responsive block copolymers affects the cooperativity and the liposomal stabilization and imparts pH responsiveness (functionality), which was confirmed by performing experiments in acidic environment (citrate buffer). In conclusion, the results from DSC measurements provide useful information regarding the quality by design process for rationally preparing mixed/chimeric liposomal platforms to incorporate bioactive molecules.
Starting Page	1381
Ending Page	1392
Page Count	12
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	127
Issue Number	2
e-ISSN	15882926
Language	English
Publisher	Springer Netherlands
Publisher Date	2017-01-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	pH-sensitive liposomes DSC Block copolymer Polyacrylic acid Drug delivery systems HSPC lipid Physical Chemistry Analytical Chemistry Polymer Sciences Inorganic Chemistry Measurement Science and Instrumentation
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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