NDLI: Rice husk ash nanosilica to inhibit human breast cancer cell line (3T3)

Content Provider	Springer Nature Link
Author	Yuvakkumar, R. Nathanael, A. Joseph Rajendran, V. Hong, S. I.
Copyright Year	2014
Abstract	NaOH treatment on phase, purity and particle size of rice husk nanosilica were investigated employing alkaline-extraction–acid-precipitation method. Mild reaction at lower NaOH (1.5 N) revealed small and fine particles (600 nm) due to moderate reaction rate. Morphology of human breast cancer cell line (3T3) revealed that suggestive cell distress effects were more pronounced at 500 µg/ml silica dosages which are in agreement with cell viability decrease (~50 %). Among different silica dosages, 10 µg/ml was found to have highest cell viability (∼70 ± 2 %) capable of increasing dissolved oxygen level while viability was almost decreased to 27 ± 5 % due to toxic effect caused at higher SiO$_{2}$ dosage and could be a potential candidate best suited for biomedical applications through development of sustainable materials.
Starting Page	198
Ending Page	205
Page Count	8
File Format	PDF
ISSN	09280707
Journal	Journal of Sol-Gel Science and Technology
Volume Number	72
Issue Number	1
e-ISSN	15734846
Language	English
Publisher	Springer US
Publisher Date	2014-08-12
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nanosilica Rice husk ash NaOH Human breast cancer cell line (3T3) Ceramics, Glass, Composites, Natural Methods Inorganic Chemistry Optical and Electronic Materials Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Chemistry Materials Chemistry Biomaterials Condensed Matter Physics Electronic, Optical and Magnetic Materials

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