NDLI: Development and evaluation of a $^{166}$holmium labelled porphyrin complex as a possible therapeutic agent

Content Provider	Springer Nature Link
Author	Vahidfar, Nassim Jalilian, Amir R. Fazaeli, Yousef Bahrami Samani, Ali Beiki, Davood Khalaj, Ali
Copyright Year	2012
Abstract	Porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. In this work, [$^{166}$Ho] labeled 5,10,15,20-tetrakis(phenyl) porphyrin ([$^{166}$Ho]-TPP) was prepared using [$^{166}$Ho]HoCl$_{3}$ and 5,10,15,20-tetrakis(phenyl)porphyrin (H$_{2}$TPP) for 12 h at 50 °C (radiochemical purity: >95 ± 2 % ITLC, >99 ± 0.5 % HPLC, specific activity: 0.9–1.1 GBq/mmol). Stability of the complex was checked in final formulation and human serum for 48 h. The partition coefficient was calculated for the compound (log P = 2.01). The biodistribution of the labeled compound in vital organs of wild-type rats was studied using scarification studies and SPECT. A detailed comparative pharmacokinetic study performed for $^{166}$Ho cation and [$^{166}$Ho]-TPP performed up to 24 h. The complex is mostly washed out from the circulation through kidneys and in less extends from the liver. The kidney:blood, kidney:liver and kidney:muscle ratios 4 h post injection were 14, 3.6 and 7.38 respectively.
Starting Page	979
Ending Page	986
Page Count	8
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	295
Issue Number	2
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-08-08
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Porphyrins $^{166}$Ho Half life Biodistribution SPECT Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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