NDLI: Effect of adenine on bacterial translocation using technetium-99m labeled E. coli in an intestinal obstruction model in rats

Content Provider	Springer Nature Link
Author	Oflaz, Uğur Yurt Lambrecht, Fatma Yilmaz, Osman Pekçetin, Çetin
Copyright Year	2012
Abstract	This study aims to investigate effects of adenine on bacterial translocation (BT) using $^{99m}$Tc-labeled E. coli in an intestinal obstruction rat model. In the study twenty-one rats were used. The rats were divided into three groups according to different feeding patterns. The control group (CG) was fed with a standard chow diet for 7 days. Group A1 and group A2 were fed with adenine supplemented chow diet for 7 days. At the end of the feeding period, after all groups was submitted intestinal obstruction. $^{99m}$Tc-E. coli was injected into the rats’ terminal ileum under anesthetic. The rats were sacrificed under aseptic conditions at 24th h after the surgery. The uptake of $^{99m}$Tc-E. coli was determined in organs such as the liver, mesenteric lymph nodes, spleen and ileum. Group A1 and group A2 results show that the uptake of $^{99m}$Tc-E. coli decreased in the blood and organs comparing to the CG. As a result, it was observed that adenine reduced the level of BT when compared with CG. The beneficial effect of adenine on BT in intestinal obstruction was observed. However, further studies are needed to more clearly assess how this benefit can be achieved.
Starting Page	959
Ending Page	964
Page Count	6
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	295
Issue Number	2
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-09-21
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bacterial translocation Intestinal obstruction Adenine Immune system Nucleotide $^{99m}$Tc-E. coli Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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