NDLI: Preparation of self-solidifying polymeric depots from PLEC-PEG-PLEC triblock copolymers as an injectable drug delivery system

Content Provider	Springer Nature Link
Author	Khamlao, Wannarong Hongeng, Suradej Sakdapipanich, Jitladda Nasongkla, rased
Copyright Year	2012
Abstract	Copolymers of (D,L-lactide-random-ε-caprolactone)-block-poy(ethylene glycol)-block-(D,L-lactide-random-ε-caprolactone) or PLEC were explored as materials for injectable drug delivery system. A series of six PLECs were successfully synthesized with varied D,L-lactide (LA) content (0, 10 and 20%) and molecular weight (20 and 50 kDa). All polymers were able to form depots with more than 90% encapsulation efficiency of trypan blue leading to the loading density as high as 27% w/w. The variation of trypan blue loading, LA content and molecular weight were found to have profound effects on trypan blue release profiles. Even though, GPC and SEM confirmed the higher degradation of PLEC chains, trypan blue release rate and burst release was greater as the content of hydrophilic moiety, i.e. LA, was decreased. This was primarily due to the smooth and dense surface and cross-section of PLEC depots. The results from this study suggest a possible application of these depots as injectable, self-solidifying drug delivery systems.
Starting Page	1
Ending Page	12
Page Count	12
File Format	PDF
ISSN	10229760
Journal	Journal of Polymer Research
Volume Number	19
Issue Number	3
e-ISSN	15728935
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-03-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Drug delivery systems Polymer gels Biodegradable polymers Depot Triblock copolymer Characterization and Evaluation of Materials Industrial Chemistry/Chemical Engineering Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Polymers and Plastics

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