NDLI: Mesoscale simulation and experimental studies of self-assembly behavior of a PLA-PEG-PLA triblock copolymer micelle for sustained drug delivery

Content Provider	Springer Nature Link
Author	Chansuna, Mantana Pimpha, Nuttaporn Vao soongnern, Visit
Copyright Year	2014
Abstract	Dissipative Particle Dynamic simulation (DPD) was employed to investigate PLA-PEG-PLA copolymer micelles to gain more understanding at the molecular level in addition to experimental studies. Critical micelle concentration (cmc), micelle size and small molecule encapsulation of these triblock copolymer micelles with different hydrophobic/hydrophilic (LA/EG) block ratios (2.56, 4.88 and 7.25 with fixed PEG length = 23 monomer units) were determined. Only the appropriated LA/EG block ratio (4.88 and 7.25) can induce the formation of spherical micelle in a dilute solution. The cmc and micelle size were decreased and increased, respectively, as a function of the LA/EG block ratio. Upon adding small solubilizate molecules, a larger micelle size was formed. Then, PLA-PEG-PLA with the same LA/EG block ratios as DPD simulation were synthesized and the micelle solution was prepared. Pyrene was used as the molecular probe to find the cmc by fluorescence spectroscopy. Light scattering was applied to determine the hydrodynamic radius (R $_{ H }$) of these micelles. The cmc and R$_{H}$ were decreased and increased, respectively, with LA/EG ratio, qualitatively similar to the trends as simulation results. The behavior of these copolymer micelles to encapsulate the small solubilizate molecules was also studied by fluorescence technique. The partition coefficients of pyrene between the water phase and the micelle core were increased with a higher LA/EG block ratio similar to results from the simulation.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	10229760
Journal	Journal of Polymer Research
Volume Number	21
Issue Number	6
e-ISSN	15728935
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-05-09
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Triblock copolymer Micelle Mesoscale simulation Drug delivery Polymer Sciences Industrial Chemistry/Chemical Engineering Characterization and Evaluation of Materials
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Polymers and Plastics

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