NDLI: Semi-interpenetrated polymer networks of hyaluronic acid modified with poly(aspartic acid)

Content Provider	Springer Nature Link
Author	Nistor, Manuela T. Chiriac, Aurica P. Nita, Loredana E. Vasile, Cornelia Bercea, Maria
Copyright Year	2013
Abstract	New hydrogels based on entrapped poly(aspartic acid) (PAS) into hyaluronic acid (HA) crosslinked network were obtained to improve the sensitive characteristics, especially the pH responsiveness of the hyaluronic gels. The interactions between the macromolecular chains were sustained by rheological test, zeta potential, and hydrodynamic diameter and conductivity determinations. In situ and static evaluation of zeta potential indicated a substantially decreases of electrokinetic potential of HA/PAS mixture solutions interpreted due to the electrostatic complexation between polypeptide and polysaccharide causing a decrease in electrostatic free energy of the system. Similar, the positive deviation from the ideal additive observed on the logarithmic graphical representation of relative viscosity corresponds to the presence of the intermolecular bonds between the macromolecular chains. The spectral analysis confirmed the hydrogels formation, while the rheological measurements of HA/PAS semi-IPN have shown formation of structured network with physical links between the polymeric copartners. The SEM microphotographs presented a homogeneous porous structures with spherical formations ordered at high concentration of PAS. The superabsorbent character of PAS is evidenced by the maximum swelling degree reached at high value of pH and high PAS content. With an advantageous decreasing of residual mass and convenient straightening for thermal stability up to 60 °C compared with hyaluronic gels, the improved properties are explicated. Figure The semi-IPN networks based on hyaluronic acid and poly(aspartic acid) present improved swelling capacities owing to the superabsorbent character of poly(aspartic acid), as well as pH sensitivity for the new polymeric systems. The semi-IPN structures are also transformed into a viscoelastic systems through the PAS insertion into the HA network.
Starting Page	1
Ending Page	11
Page Count	11
File Format	PDF
ISSN	10229760
Journal	Journal of Polymer Research
Volume Number	20
Issue Number	2
e-ISSN	15728935
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-01-29
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hyaluronic acid Poly(aspartic acid) Divinyl sulphone pH-sensitive gel Viscous properties Polymer Sciences Industrial Chemistry/Chemical Engineering Characterization and Evaluation of Materials
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Polymers and Plastics

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