NDLI: Polymeric Conjugates of Selected Aminoquinoline Derivatives as Potential Drug Adjuvants in Cancer Chemotherapy

Content Provider	Springer Nature Link
Author	Aderibigbe, Blessing A. Jacques, Kayembe D. Neuse, Eberhard W.
Copyright Year	2011
Abstract	In the chemotherapy of cancerous diseases, the clinical co-administration of an active anti-tumor drug with other compounds acting as potentiating agents or adjuvants has demonstrated considerable merits in comparison with single-drug administration. Selected members of the 4- and 8-aminoquinoline-based class of antimalarials, such as chloroquine and hydroxychloroquine, have been identified as providers of such adjuvant effects in combination with certain standard antitumor drugs, although no significant clinical experiences have as yet been reported. The here described project aims at the synthesis of water-soluble macromolecular carriers to which selected aminoquinolines are bioreversibly conjugated together with cytotoxic drug species exemplified by a diaminoplatinum(II) complex and by the organoiron compound, ferrocene, the latter being a relative newcomer to the family of organometallic antineoplastic agents. As most medicinal agents differ from each other by their pharmacokinetic path and, therefore, experience different rates and degree of body distribution and organ accumulation, the simultaneous availability of two or more mutually potentiating drug species can best be achieved if a common transport vehicle, such as a multifunctional carrier polymer of the type synthesized in this study, is utilized for this purpose. The conjugates and co-conjugates, isolated by conventional methods as water-soluble solids, are compositionally characterized by NMR-spectroscopic and microanalytical techniques.
Starting Page	336
Ending Page	345
Page Count	10
File Format	PDF
ISSN	15741443
Journal	Journal of Inorganic and Organometallic Polymers and Materials
Volume Number	21
Issue Number	2
e-ISSN	15741451
Language	English
Publisher	Springer US
Publisher Date	2011-02-09
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	8-aminoquinolines 4-aminoquinolines Ferrocene Platination reaction 4-aminoquinoline homoconjugates 8-aminoquinoline homoconjugates Polymeric co-conjugates Drug adjuvants Polymer Sciences Organic Chemistry Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Materials Chemistry Polymers and Plastics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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