NDLI: Poly(ethylene Oxide)-Modified Polyaspartamide

Content Provider	Springer Nature Link
Author	Meirim, Maria G. Neuse, Eberhard W. Caldwell, Gregg A.
Copyright Year	1997
Abstract	In continuation of earlier investigations of polymer–ferrocene conjugates for biomedical applications, this article deals with conjugates prepared by N-acylation of linear, amine-functionalized polyaspartamide carriers with 4-ferrocenylbutanoic acid. Acylation is brought about both by mediation of HBTU coupling agent and by the N-hydroxysuccinimide active ester method. The polymeric carriers contain oligo- or poly(ethylene oxide) side chains introduced here for enhancement of water solubility. The longer side chains, in addition, are to impart such biomedically important properties as increased resistance to uptake by the reticuloendothelial system and to protein binding, extended circulation life time, and lowered immunogenicity. The conjugates comprise from 10 to 25 mol% ferrocenylated subunits, corresponding to ca. 2–5% Fe by mass. Freshly prepared and isolated in the solid state, they dissolve smoothly in aqueous media, with upper concentration limits (>0.2g/ml) dictated solely by their viscosity behavior. The conjugates are of interest in biomedical applications.
Starting Page	71
Ending Page	91
Page Count	21
File Format	PDF
ISSN	10530495
Journal	Journal of Inorganic and Organometallic Polymers and Materials
Volume Number	7
Issue Number	2
e-ISSN	15728870
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1997-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Inorganic Chemistry Organic Chemistry Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Materials Chemistry Polymers and Plastics

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