NDLI: Comparative analysis of the nigrostriatal system in Wistar rats and rats prone to seizures

Content Provider	Springer Nature Link
Author	Dorofeeva, N. A. Glazova, M. V. Khudik, K. A. Nikitina, L. S. Kirillova, O. D. Chernigovskaya, E. V.
Copyright Year	2015
Abstract	—Functional activities of dopaminergic, GABAergic and glutamatergic neurons were studied in the nigrostriatal system of Krushinsky–Molodkina (KM) rats genetically prone to audiogenic seizures as compared with control Wistar rats. In KM rats, a reduced activity of GABA-and dopaminergic neurons was detected in the substania nigra, while glutamatergic transmission remained intact. In the striatum of both KM and Wistar rats, no significant differences were found in levels of the GABA-synthesizing enzymes, GAD65/67 and phospho-tyrosine hydroxylase, however, an increased level of D1 dopamine receptor and decreased of D2 dopamine receptor imply possible upregulation of glutamatergic neurotransmission. Indeed, an increased expression of vesicular glutamate transporter VGlut2 and the NMDA receptor NR2B subunit was revealed in the striatum of KM rats. While the striatum glutamatergic fibers were demonstrated to express phosphorylated ERK1/2 kinases, both the striatum and substantia nigra in KM rats exhibit an increased activity of ERK1/2. This correlates with intense exocytosis, as evidenced by a decreased level of SNAP25 protein. Activation of the glutamatergic system may result, among other reasons, from the disruption of the inhibitory effect of the substantia nigra dopamine- and GABAergic systems innervating the striatum. We suggest that the increased activity of the striatum glutamatergic neurons in KM rats lacking adequate dopamine- and GABAergic inhibitory feedback may, at least in part, account for heightened convulsive readiness in KM rats.
Starting Page	235
Ending Page	245
Page Count	11
File Format	PDF
ISSN	00220930
Journal	Journal of Evolutionary Biochemistry and Physiology
Volume Number	51
Issue Number	3
e-ISSN	16083202
Language	English
Publisher	Pleiades Publishing
Publisher Date	2015-08-01
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	epilepsy glutamate dopamine ERK1/2 GABA Evolutionary Biology Biochemistry Animal Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Biochemistry Ecology, Evolution, Behavior and Systematics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hemo-rheological status of young Wistar–Kyoto rats

P53 Inactivation leads to enhancement of tyrosine hydroxylase biosynthesis in brain dopaminergic neurons

Modulating effect of dopamine on amplitude of GABA-produced chemocontrolled currents in multipolar spinal cord neurons of ammocaete

Comparative analysis of various hemoglobins: Autoxidation and spectral properties

Biochemical and genetic aspects of pathogenesis of schizophrenia

Convergence of modulating influences of presynaptic metabotropic and GABA$_{B}$-receptors

On “Pathomorphosis” of Cataleptic Response in Rats

The role of inducible Hsp70 protein in modulation of neurodegenerative pathology in the nigrostriatal system typical to Parkinson’s disease

Role of Bcl-2 in the regulation of CREB activity and vasopressin expression in hypothalamic neurons

Comparative analysis of the nigrostriatal system in Wistar rats and rats prone to seizures

Similar Documents

Hemo-rheological status of young Wistar–Kyoto rats

P53 Inactivation leads to enhancement of tyrosine hydroxylase biosynthesis in brain dopaminergic neurons

Modulating effect of dopamine on amplitude of GABA-produced chemocontrolled currents in multipolar spinal cord neurons of ammocaete

Comparative analysis of various hemoglobins: Autoxidation and spectral properties

Biochemical and genetic aspects of pathogenesis of schizophrenia

Convergence of modulating influences of presynaptic metabotropic and GABA$_{B}$-receptors

On “Pathomorphosis” of Cataleptic Response in Rats

The role of inducible Hsp70 protein in modulation of neurodegenerative pathology in the nigrostriatal system typical to Parkinson’s disease

Role of Bcl-2 in the regulation of CREB activity and vasopressin expression in hypothalamic neurons

Comparative analysis of the nigrostriatal system in Wistar rats and rats prone to seizures