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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zeng, Xue Qi Zhang, Chun Mei Tong, Mei Ling Chi, Xia Li, Xi Ling Ji, Chen Bo Zhang, Rong Guo, Xi Rong |
| Copyright Year | 2012 |
| Abstract | NYGGF4, an obesity-related gene, is proposed to be involved in the development of insulin resistance. Skeletal muscle is a primary target organ for insulin and NYGGF4 showed a relatively high expression level in skeletal muscle. Therefore, this study aimed to explore the effect of NYGGF4 on insulin sensitivity of skeletal muscle cells. RNA interference (RNAi) was adopted to silence NYGGF4 expression in mice C2C12 skeletal myocytes. A remarkably increased insulin-stimulated glucose uptake and GLUT4 translocation was observed in NYGGF4 silencing C2C12 cells. Importantly, the enhanced glucose uptake induced by NYGGF4 silencing could be abrogated by the PI3K inhibitor LY294002. In addition, the crucial molecules involved in PI3K insulin signaling pathway were detected by western blotting. The results showed that NYGGF4 knockdown dramatically activate the insulin-stimulated phosphorylation of IRS-1 and AKT. Taken together, these data demonstrate that NYGGF4 knockdown increases glucose transport in myocytes by activation of the IRS-1/PI3K/AKT insulin pathway. |
| Starting Page | 351 |
| Ending Page | 355 |
| Page Count | 5 |
| File Format | |
| ISSN | 0145479X |
| Journal | Journal of Bioenergetics and Biomembranes |
| Volume Number | 44 |
| Issue Number | 3 |
| e-ISSN | 15736881 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-04-18 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | NYGGF4 Glucose uptake Insulin signaling Skeletal myocytes Animal Biochemistry Biochemistry Bioorganic Chemistry Animal Anatomy / Morphology / Histology Organic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology |
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